The Handbook of Alzheimer′s Disease and Other Dementias

Dr. Neil W. Kowall is Chief of Neurology and Director of the New England GRECC at the VA Boston Healthcare System; he is also Director of the NIH-funded Boston University Alzheimer's Disease Center, Professor of Neurology and Pathology at Boston University School of Medicine, and Lecturer in Neurology at Harvard Medical School. He has published over 170 papers in peer-reviewed journals including Science, Nature, the Journal of Neuroscience, and the Annals of Neurology. Dr. Andrew E. Budson is the Deputy Chief of Staff and a member of the Geriatric Research Education Clinical Center (GRECC) at the VA Boston Healthcare System. He is also Associate Director for Research at the Boston University Alzheimer's Disease Center, Professor of Neurology at Boston University School of Medicine, and Lecturer in Neurology at Harvard Medical School. He was awarded the 2008 Norman Geschwind Prize in Behavioral Neurology and the 2009 Research Award in Geriatric Neurology, both from the American Academy of Neurology, and has published over 75 papers in peer-reviewed journals including the New England Journal of Medicine, Brain, and Cortex.

Contributors ix Foreword xii Preface xv Part I Common Dementias 1 1 Alzheimer s Disease 3 Alan M. Mandell and Robert C. Green 2 Vascular Dementia 92 Angela L. Jefferson, Amanda M. Gentile, and Ravi Kahlon 3 Dementia with Lewy Bodies 131 Tamara G. Fong and Daniel Z. Press 4 Frontotemporal Dementia 145 Adam L. Boxer 5 Other Dementias 179 Peter Morin Part II Pathogenesis and Disease Mechanisms 195 6 Genetic Risk Factors for Dementia 197 Paul Hollingworth and Julie Williams 7 The Neuropathology of the Dementing Disorders 235 Ann C. McKee and Brandon E. Gavett 8 Amyloid Beta Peptide and the Amyloid Cascade Hypothesis 262 Carmela R. Abraham 9 Other Mechanisms of Neurodegeneration 277 Marina Boziki, Vassilis Papaliagkas, and Magda Tsolaki 10 Rational Therapeutics for Alzheimer s Disease and Other Dementias 301 Neil W. Kowall Part III Cognitive and Behavioral Dysfunction 313 11 Memory Dysfunction in Dementia 315 Andrew E. Budson 12 Language Processing in Dementia 336 Jamie Reilly, Joshua Troche, and Murray Grossman 13 Executive Functioning 369 Robert A. Stern, Stacy L. Andersen, and Brandon E. Gavett 14 Emotion and Behavior in Alzheimer s Disease and Other Dementias 416 Christopher I. Wright 15 Visuospatial Function in Alzheimer s Disease and Related Disorders 457 Alice Cronin-Golomb 16 Sleep and Circadian Rhythms in Dementia 483 David G. Harper Part IV Neuroimaging in Dementia 505 17 Glimpses of the Living Brain with Alzheimer s Disease 507 Ronald J. Killiany 18 Functional MRI in Alzheimer s Disease and Other Dementias 535 Maija Pihlajamaki and Reisa A. Sperling 19 Molecular Neuroimaging of the Dementias 557 Bradford C. Dickerson 20 Using EEG and MEG to Understand Brain Physiology in Alzheimer s Disease and Related Dementias 575 Brandon A. Ally Index 604 Plate section between pages 304 and 305