Experimental Studies on Guinea Pig's Eczema

Material and Technique.- A. Choice of Animal.- B. Macroscopic Control of Sensitization (Patch Test).- C. Histological Control of Sensitization.- I. Experimentation with Dinitrochlorobenzene (DNCB).- A. Method of Sensitization.- 1. Methods Employed in Our Studies.- a) Application of a Primary Toxic Solution.- b) Application of a Primary Non-Toxic Solution.- 2. Other Methods.- a) Sensitization by Epidermal Applications.- b) Sensitization by Injections.- c) Sensitization by Injections of DNCB Combined with Epicu- taneous Applications of a DNCB Solution..- d) Complex Methods of Sensitization.- B. Primary Toxic Reaction in Unsensitized Guinea Pigs.- 1. Evolution of Lesions. Histological Examination of Primary Toxic Lesions.- a) Flank.- b) Nipple.- 2. The Primary Toxic Effect and Acanthosis.- a) Flank.- b) Nipple.- 3. The Primary Toxic Reaction and Mitosis.- C. Specific Reaction of Sensitization ("Eczematous Reaction", "Delayed Reaction").- 1. Patch Test.- 2. Histological Examination of the Eczematous Reaction.- a) Flank.- b) Acanthosis of Flank.- c) Nipple: Evolution of Lesions.- d) Acanthosis of the Nipple.- e) The Specific Reaction of Sensitization and Mitosis.- D. The Histological Lesions of the Epidermis and Dermis.- 1. Spongiosis.- 2. Intra-Epidermal Vesicles.- 3. Subcorneal Vesicles.- 4. Dermal Infiltrate.- E. Sensitization of New Born Guinea Pigs (Small Subcorneal Vesicles) 21 Results.- a) Macroscopy.- b) Histology.- F. Appearance of Histological Eczematous Reactions During Sensitization.- G. Sensitization by Multiple Applications on the Nipple.- II. Experimentation with Other Substances.- A. Sensitization with Paranitrosodimethylaniline (PNDMA).- 1. Method of Sensitization.- 2. Primary Toxic Reaction.- 3. Specific Reaction due to Sensitization.- a) Macroscopic Reaction.- b) Histological Examination.- B. Sensitization with Citraconic Anhydride (CA).- 1. Method of Sensitization.- 2. Primary Toxic Reaction.- 3. Specific Reaction due to Sensitization.- Histological Examination.- C. Sensitization with Propionic Anhydride (PA).- 1. Method of Sensitization.- 2. Primary Toxic Reaction.- 3. Specific Reaction of Sensitization.- Histological Examination.- D. Sensitization with Paraphenylenediamine.- 1. Method of Sensitization.- 2. Primary Toxic Reaction.- 3. Specific Reaction of Sensitization.- Histological Examination.- E. Experiments Concerning Sensitization to Nickel.- Methods and Results of Sensitization.- F. Sensitization with Hexavalent Chromium.- 1. Method of Sensitization.- 2. Results.- G. Sensitization with Two Eczematogens.- 1. Dinitrochlorobenzene (DNCB) Followed by Paranitrosodimethylaniline (PNDMA).- 2. Paranitrosodimethylaniline (PNDMA) Followed by Dinitrochlorobenzene (DNCB).- 3. Citraconic Anhydride (CA) Followed by Dinitrochlorobenzene (DNCB).- III. Hematological Observations (Dinitrochlorobenzene, Citraconic Anhydride and Propionic Anhydride).- A. Eosinophils.- B. Basophils.- C. Lymphocytes.- IV. Comparison and Discussion of the Results of the Various Sensitizations.- A. Macroscopic Test.- B. Histological Examination.- C. Hematological Variations.- V. Remarks on Passive Transfer.- VI. Influence of Various Factors on Sensitization.- A. Influence of Corticosteroids.- B. Influence of X-Rays.- VII. Desensitization.- A. General Desensitization.- B. "Local Desensitization".- C. Duration of Desensitization and Resensitization.- Remark.- VIII. Discussion of Some Questions.- IX. Conclusion.- Literature.- Material and Technique.- I. Experimentation with Dinitrochlorobenzene (DNCB).- II. Experimentation with Other Substances.- III. Hematological Observations (Dinitrochlorobenzene, Citraconic Anhydride and Propionic Anhydride).- IV. Comparison and Discussion of the Results of the Various Sensitizations.- V. Remarks on Passive Transfer.- VI. Influence of Various Factors on Sensitization.- VII. Desensitization.- VIII. Discussion of Some Questions. IX. Conclusion.- Author Index.