Handbook of Marine Natural Products

Professor T. Molinski received his PhD at the Australian National University in 1984. After a postdoctoral fellowship at UC in San Diego and at the University of Utah he started at the UC Davis where he became full professor in 1997. His research interest are bioorganic chemistry, marine natural products, NMR and structure elucidation, structure--activity and synthesis.

VOLUME1 Section I Acquisition, Production, and Purification of MNP's Isolation, purification strategies for MNP's -- lipophilic and water soluble compounds LC--NMR--MS and Parallel Chromatography -- automated HTS strategies High--Throughput Screening Strategies for Microbial Natural Products Detection, isolation, purification of marine toxins -- dinoflagellates MNP's of Marine Actinomycetes -- Culture, Fermentation Cyanobacteria Aquaculture of Marine Macroorganisms -- Lissodendoryx sp., Bugula neritina, Ecteinascidia turbinata Intellectual Property and Agreements Section II Structural Studies of MNPs 2D NMR strategies methods for assignment of structure J--based analysis for Configurational Analysis Absolute Configuration of Alcohols, Amines and Carboxylic Acids-- NMR of Anisotropic Arylacetyl Derivatives Absolute Configuration from Exciton Coupling Circular Dichroism (ECCD) Degradative Strategies for Elucidation of Complex MNP's -- Shigeki Matsunaga Synthetic Strategies for Configurational Analysis Mass spectrometry of marine natural products A Universal 13C NMR Database for MNP's NMR of Sub--Nanomole Natural Products or 15N--Edited NMR at Natural Abundance Synthesis of Hybrid--MNP Combinatorial Libraries VOLUME 2 Section I Molecular Pharmacology and Biomedical Potential of Marine Natural Products Mining the human genome DNA--RNA interactions of MNP's Antiinflammatory Marine Compounds -- Pharmacology of Arachidonate Cascade Inhibitors Antifungal Marine Natural Products Antitumor MNP's -- Intervention in Signal Transduction, Cell--cycle Progression, Apoptosis Actin and Microtubule Inhibitors Ion--channel Modulators Case Study in Drug Development 1. -- Ecteinascidin 743, an Antitumor Drug from Ecteinascidia turbuinata Case Study in Drug Development. 2. -- An Analgesic Drug from Conus sp. Cooperative Industry--Government Drug Development Section II Methods in Chemical Ecology Strategies for Field Studies and Experimental Design Antifeedant MNP's Biofilms, Foundation Communities and Antifouling-- Strategies for Assay, Discovery, Development Microbial Symbionts -- Characterization of Microbial Communities Section III: Methods in Biosynthesis of Marine Natural Products Polyketide Synthase-- strategies for characterization in marine systems Biosynthesis of Bryostatin 1 by an Endosymbiont of the Bryozoan, Bugula neritina Biosynthesis in Marine Microbes -- biosynthetic pathways Biosynthesis of Marine Isoprenoids Biosynthesis of Marine Alkaloids