Cardiovascular Specific Gene Expression

1. Cardiology approaching the year 2000. A clinician’s look at molecular cardiology.- One: Cardiovascular specific gene expression.- 2. The transcriptional building blocks of the heart.- 3. A cardiac-specific troponin I promoter. Distinctive patterns of regulation in cultured fetal cardiomyocytes, adult heart and transgenic mice.- 4. Mice deficient in muscle LIM protein (MLP) reveal a pathway to dilated cardiomyopathy and heart failure.- 5. Regulation of endothelial cell specific receptor tyrosine kinase gene expression during development and disease.- 6. Smoothelins: one gene, two proteins, three muscle cell types .... so far.- Two: Transcription regulation.- 7. Regionalization of transcriptional potential in the myocardium: ‘cardiosensor’ transgenic mice.- 8. Human troponin genes: transcriptional regulation and chromosomal organization.- 9. Retinoid signaling: insight from genetically engineered mice.- 10. Ventricular expression of the atrial regulatory myosin light chain gene.- 11. Expression of rat gap junction protein connexin 40 in the heart.- three: Ion channels and gap junction.- 12. Sympathetic regulation of cardiac delayed rectification: relationship to cardiac arrhythmias.- 13. The sarco(endo)plasmic reticulum Ca2+ pumps in the cardiovascular system.- 14. Potassium channels; genes, proteins, and patients.- 15. Expression of Cx43 in cardiac and aortic muscle cells of hypertensive rats.- 16. Genetic engineering and cardiac ion channels.- four: Intracellular signaling.- 17. Receptor tyrosine kinase signaling in vasculogenesis and angiogenesis.- 18. Molecular analysis of vascular development and disorders.- 19. Crosstalk between the estrogen receptor and the insulin-like growth factor (IGF-1) receptor. Implications for cardiac disease.- 20. Expression ofbasic helix-loop-helix proteins and smooth muscle phenotype in the adult rat aorta.- 21. Expression of the IGF system in acute and chronic ischemia.- 22. Long-chain fatty acids and signal transduction in the cardiac muscle cell.- five: DNA transfer.- 23. Reduction of kidney renin expression by ribozymes.- 24. Receptor-dependent cell specific delivery of antisense oligonucleotides.- 25. Tissue-specific gene delivery by recombinant adenoviruses containing cardiac-specific promoters.- 26. Catheter-mediated delivery of recombinant adenovirus to the vessel wall to inhibit restenosis.