A Pharmacology Primer
Academic Press Inc (Verlag)
978-0-12-374585-9 (ISBN)
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This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments.The ideal book for researchers in drug discovery who have seen their role shift from "individual" to "team player" where that team includes chemists, biologists, and others with strong, but varied, science backgrounds who must now work together toward their common pharmacology goal. At GlaxoSmithKline, a pharmaceuticals world-leader, Terry Kenakin regularly teaches a course for their research scientists and has drawn on his experience to create a pharmacology primer.
Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.
Chapter 1: What is Pharmacology?Chapter 2: How Different Tissues Process Drug Response Chapter 3: Drug Receptor TheoryChapter 4: Pharmacological Assay Formats: Binding Chapter 5: Agonists: The Measurement of Affinity and Efficacy in Functional Assays Chapter 6: Orthosteric Drug Antagonism Chapter 7: Allosteric Drug Antagonism Chapter 8: The Process of Drug DiscoveryChapter 9: PharmacokineticsChapter 10: Target- and System-based Strategies for Drug DiscoveryChapter 11: ‘Hit’ to Drug: Lead OptimizationChapter 12: Statistics and Experimental DesignChapter 13: Selected Pharmacological MethodsChapter 14: Exercises in Pharmacodynamics and PharmacokineticsGlossary of Pharmacological TermsAppendices:Statistical TablesMathematical Fitting Functions
Erscheint lt. Verlag | 19.2.2009 |
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Verlagsort | San Diego |
Sprache | englisch |
Maße | 216 x 276 mm |
Gewicht | 1430 g |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
Medizin / Pharmazie ► Pharmazie | |
ISBN-10 | 0-12-374585-3 / 0123745853 |
ISBN-13 | 978-0-12-374585-9 / 9780123745859 |
Zustand | Neuware |
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