DNA Methylation Research Trends
Seiten
2007
Nova Science Publishers Inc (Verlag)
978-1-60021-721-0 (ISBN)
Nova Science Publishers Inc (Verlag)
978-1-60021-721-0 (ISBN)
DNA methylation is a type of chemical modification of DNA that can be inherited without changing the DNA sequence. As such, it is part of the epigenetic code and is the most characterised epigenetic mechanism. DNA methylation involves the addition of a methyl group to DNA. This book presents research from around the world in this field.
DNA methylation is a type of chemical modification of DNA that can be inherited without changing the DNA sequence. As such, it is part of the epigenetic code and is the most characterised epigenetic mechanism. DNA methylation involves the addition of a methyl group to DNA -- for example, to the number 5 carbon of the cytosine pyrimidine ring. DNA methylation is probably universal in eukaryotes. In humans, approximately 1% of DNA bases undergo DNA methylation. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells.In plants, cytosines are methylated both symmetrically (CpG or CpNpG) and asymmetrically (CpNpNp), where N can be any nucleotide. The methylation status of specific cytosines can be determined using methods based on bisulfite sequencing. This book presents new and important research from around the world in this field.
DNA methylation is a type of chemical modification of DNA that can be inherited without changing the DNA sequence. As such, it is part of the epigenetic code and is the most characterised epigenetic mechanism. DNA methylation involves the addition of a methyl group to DNA -- for example, to the number 5 carbon of the cytosine pyrimidine ring. DNA methylation is probably universal in eukaryotes. In humans, approximately 1% of DNA bases undergo DNA methylation. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells.In plants, cytosines are methylated both symmetrically (CpG or CpNpG) and asymmetrically (CpNpNp), where N can be any nucleotide. The methylation status of specific cytosines can be determined using methods based on bisulfite sequencing. This book presents new and important research from around the world in this field.
Preface; Research and Review Studies; Investigation of the CpG Effect in Mammalian Genomes; CpG Islands in Plants; Epigenetic Roles of CpG Methylation at Non-CpG-Islands revealed by Morphology-Oriented Epigenetic Research; DNA Methyltransferase Inhibitors as Therapeutic Agents in Hematological Malignancies; Analysis of DNA Methylation Patterns for the Early Diagnosis, Classification and Therapy of Human Cancers; DNA Methylation Changes in Pathogenesis and Therapy of Hematopoietic Malignancies; DNA Methylation and Tumour Suppression; Methylation and Loss of Heterozygosity in Cancer are linked by siRNA?; Methylation in Cancer Research; Index.
Erscheint lt. Verlag | 1.12.2007 |
---|---|
Zusatzinfo | Illustrations, unspecified |
Verlagsort | New York |
Sprache | englisch |
Maße | 260 x 180 mm |
Gewicht | 782 g |
Themenwelt | Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik |
ISBN-10 | 1-60021-721-4 / 1600217214 |
ISBN-13 | 978-1-60021-721-0 / 9781600217210 |
Zustand | Neuware |
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