Biology of Aging and Development

Session I Theoretical Concepts of Developmental and Age Changes.- Implications of aging research for society.- Current theories of biological aging.- Towards a theory of development.- Session II Gene Regulation in Differentiation and Development.- Introductory remarks.- Surface reorganization as an initial inductive event in the differentiation of prothymocytes to thymocytes.- Germ line basis for antibody diversity.- Sequential expression of germ line genes in development of immunoglobulin class diversity.- Normal and altered phenotypic expression of immunoglobulin genes.- Expression of specific clones during B cell development.- Session III Finite Versus Infinite Proliferative and Functional Capacities of Cells.- Growth and death of diploid and transformed human fibroblasts.- Pathological implications of cell aging in vitro.- Unlimited division potential of precancerous mouse mammary cells after spontaneous or carcinogen-induced transformation.- Restricted replicative life-span of diabetic fibroblasts in vitro: its relation to microangiopathy.- Hayflick's hypothesis: an approach to in vivo testing.- Contributions of cytoplasmic factors to in vitro cellular senescence.- Session IV Aging of Homeostatic Control Systems.- Introductory remarks.- Age-related changes in thermoregulatory capacity of tryptophan-deficient rats.- Zinc deficiency and brain development in the rat.- Neuronal-glial interactions during development and aging.- Pituitary inhibitor of thyroxine.- Bioenergetic functions of sleep and activity rhythms and their possible relevance to aging.- Changes in monoamine oxidase and monoamines with human development and aging.- Procaine HCl (Gerovital H3): a weak, reversible, fully competitive inhibitor of monoamine oxidase.- Discussion of papers on aging of homeostatic control systems.- Session V Development and Aging in Organ Systems.- Ontogeny of mouse T-lymphocyte function.- Differentiation of thymus cells.- Development of B lymphocytes.- Ontogeny of B-lymphocyte function with respect to the heterogeneity of antibody affinity.- Effects of aging on the differentiation and proliferation potentials of cells of the immune system.- Age-related changes, including synergy and suppression, in the mixed lymphocyte reaction in long-lived mice.- Panel discussion on T-cell heterogeneity.- Session VI Development and Aging at the Molecular Level.- Development and aging at the molecular level.- Hormonal regulation of hepatic P-enolpyruvate carboxykinase (GTP) during development.- Pre- and postnatal enzyme capacity for drug metabolite production.- Impaired hormonal regulation of enzyme activity during aging.- Age-related changes in glucocorticoid binding by rat splenic leukocytes: possible cause of altered adaptive responsiveness.- Covalent modification of nuclear proteins during aging.- Effects of aging on ionic movements of atrial muscle.- Enzymatic studies on the skeletal myosin A and actomyosin of aging rats.