Global Trends in Health, Technology and Management

Dr. A.K. Saxena, Chairman, GIPER, Kashipur, Ex-emeritus and Chief Scientist CDRI, Lucknow, India is actively involved in Medicinal Chemistry & Computer Aided Drug Design (CADD). He has, more than, 50 years of research experience with, >270 publications, 72 patents, >200 invited lectures, >55 sessions chaired. He has supervised >200 post graduates and 45 PhD students and has made >60 visits abroad. Dr. Saxena initiated QSAR and the concepts of CADD as early as in 1974 in India and made major contributions for its development and has founded Global Institute of Pharmaceutical Education and Research, Kashipur, India. He is the recipient of several awards, including Humboldt Fellowship, INSA Medal, Themis Chemicals UDCT, Ranbaxy Research Award, an Honorary Medal for outstanding contributions to Medicinal Chemistry and ISC, Russia and Prof. P.K. Bose Memorial Award. He is the Fellow of the Royal Society of Chemistry (FRSC), UK, and is also the series editor for book series "TMC" published by Springer. He is the Editorial Board Member of journals MCR, SAR and QSAR, CTMC and ARKIVOC. He is member of several committees including ACS.

Prof. (Dr.) Sisir Nandi completed Ph.D. from Indian Institute of Chemical Biology (CSIR), India and had been awarded Ph.D. in Pharmacy degree (2010) by the Jadavpur University, India. He did his Post-Doctoral research as the European Union Marie Curie fellowship in Laboratory of Chemometrics, National Institute of Chemistry, Ljubljana, Slovenia, Europe. His specialization is Pharmaceutical Chemistry. Dr. Nandi is working in the area of QSAR, anti-COVID-19, anticancer, antiviral,  antitubercular, antimalarial drug design, development and discovery research, biological activity prediction of lead compounds, ligand-receptor interactions, virtual screening, combinatorial library design and lead-hopping. He has published more than 125 original research articles and reviews in reputed international journals having high impact factor. He has published 8 book chapters with SpringerNature and Bentham books. He has presented his research work in many international conferences around the world. He is Editorial advisory board member of many reputed journals. He is having more than 15 years of teaching and 20 years of research experiences. He has been guiding many master's and doctoral students. He is very competent in organizing many government funded international seminar, conferences and symposia as organizing Secretary (CPDDP-2014, CMTPI-2017; CTPMS-2020, DDDR-2021, GTHTM-2024). He has been working with government funded research projects.

Chapter 1 Quantitative Structure Interaction Activity Relationship (QSIAR) a Novel Approach to Drug Design: A Case Study of Anti-tubercular Agents.- Chapter 2 ONCORx: A digital App for cancer treatment planning.- Chapter 3 Amprenavir-Ritonavir combination is more effective in Leishmania donovani compared to Leishmania major.- Chapter 4 A Hands-on Perspective on Physico-Chemical Versus AI/ML Methods along the Genome to Drug Pathway.- Chapter 5 Elucidation of the Binding Modes of Known Potent Inhibitors at Mycobacterial FOF1-ATP Synthase Subunits c and .- Chapter 6 Docking-based experimental approach examining the effectiveness of nano-formulations as diabetes therapeutics.- Chapter 7 Nano-phytocompound combats food-additive induced genotoxicity and mitochondrial dysfunction in diabetic model: an in silico predicted experimental study.- Chapter 8 Optimizing solubility through co-crystal technology: A rigorous investigation into tablets loaded with azelnidipine co-crystals.- Chapter 9 Natural product and their derivatives: Promising caspase-3 activators as anticancer agents.- Chapter 10 Modeling of the Cyclic Guanidines As 5-HT5A Receptor Ligands Using Chemometric Tools.- Chapter 11 Computer-Aided Drug Design of Potential Anti-tubercular Drug Targeting the Mycobacterial F-type ATP Synthase Enzyme.- Chapter 12 Natural drugs to combat Dengue Fever.- Chapter 13 Development and Assessment of Nanostructured Lipid Carriers loaded with Calotropis gigantea Extract for the Enhancement of Therapeutic Effect.- Chapter 14 Identification of Novel Potent KRASG12D Inhibitors Through Target-Based Virtual Screening.- Chapter 15 Oncolytic Viral Therapy: A Promising Approach in Cancer Treatment.- Chapter 16 QSAR of repurposed AntiCOVID-19 chemotherapeutics utilizing theoretical structural descriptors.- Chapter 17 Nanosuspension Formulation - ActivityRelationship of anticancercompounds to enhance therapeutic efficacy of gastric cancer.- Chapter 18 Effects of commonly used pesticides on gut microbiota.- Chapter 19 Pharmacophore Modeling of Tricyclic Antipsychotics.- Chapter 20 Novel synthesis of 3,5-disubstituted-5H-thiazolo[3, 2 - ]pyrimidine.- Chapter 21 Insights into the Structure and Function of ClpP from the Mycobacterium genus.- Chapter 22 Novel Synthesis of 1-arylnaphtho[1,2-d]isoxazole through oxidation of 1-amidoalkyl-2-naphthols using MnO2.