Immune Responses to Viral Vectors Used in Gene Therapy

Can the creativeness of gene therapists overcome the evolutionary advantage of the immune system? Gene therapy as clinical pharmacology and treatment of disease: Quo vadis?- Introductory overview: How the immune responses to viruses informs the use of viral vectors in gene therapy.- Immune responses to adenoviral vectors in the brain.- Innate and adaptive immune responses to adenoviral vectors administered systemically: cellular and molecular mechanisms.- The immune responses to adenoviral vectors: the clinical experience.- Immune responses to AAV vectors in the CNS.- Immune responses to AAV: experimental approaches and clinical implications.- Immune control of HSV: implications for gene therapy.- Immune responses to HSV vectors: implications for clinical trials of brain tumors.- Immune responses to HSV1-derived amplicon vectors.- Control of immune responses to lentiviral vectors administered systemically.- Innate immune responses to retroviral vectors.- The genetics of the immune responses to viral vectors in gene therapy.- Induction of tolerance to gene therapy and therapeutic products.