Handbook of Opioid Bowel Syndrome
Haworth Press Inc (Verlag)
978-0-7890-2128-1 (ISBN)
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This groundbreaking book will help physicians in their day-to-day practice and help researchers and educators prepare the next generation of clinicians to make more efficient use of opioids. The Handbook of Opioid Bowel Syndrome presents complete, authoritative, current information on the mechanisms of action of opioids and the management of opioid bowel dysfunction-the number one reason physicians avoid prescribing opioids. Most chapters include charts, tables, and/or illustrations that make complex information about this vexing problem easy to access and understand. All are well-referenced for further study.
From the editor: Opioid compounds, which are widely administered for a variety of medical indications, are associated with a number of side effects, especially opioid bowel dysfunction (OBD). Very often, OBD is so severe that physicians limit opioid use or dose, even when medically indicated. Although OBD is a significant clinical problem, it has received insufficient attention in the past within the medical community. This book presents complete, authoritative information on recent progress in understanding the mechanisms of action of opioids in relation to OBD and its management.
In 11 well-referenced chapters, the Handbook of Opioid Bowel Syndrome addresses:
gastrointestinal opioid physiology and pharmacology
the pathophysiology of opioid-induced bowel dysfunction
the epidemiology of OBD
OBD in palliative care
OBD in acute and chronic nonmalignant pain
post-operative OBD
post-surgical bowel dysfunction in the gynecological patient
new peripheral opioid antagonists currently under clinical development
Packed with information about opioids that was previously unavailable or difficult to find, the Handbook of Opioid Bowel Syndrome is an essential addition to the library of any clinician, researcher, or educator who needs current, essential knowledge about the best ways to utilize these quality-of-life enhancing medications.
About the Editor
Contributors
Preface
Introduction (Chun-Su Yuan and Marco Pappagallo)
SECTION I: BASIC CONCEPTS IN OPIOID BOWEL DYSFUNCTION
Chapter 1. Gastrointestinal Opioid Physiology and Pharmacology (Keri L. Fakata and Arthur G. Lipman)
Gastrointestinal Physiology
Opioid Effects on the Gastrointestinal System
Exogenous Opioid Effects on the Gastrointestinal System
Chapter 2. Pathophysiology of Opioid-Induced Bowel Dysfunction (Sangeeta R. Mehendale and Chun-Su Yuan)
Gastrointestinal Dysfunction Caused by Exogenous Opioids
Role of Endogenous Opioids in Normal and Impaired Gut Function
Chapter 3. Opioid-Induced Immunosuppression (Gang Wei, Jonathan Moss, and Chun-Su Yuan)
Studies of Opioid-Induced Immunosuppression
Is Opioid-Induced Immunosuppression Centrally Mediated?
Is Opioid-Induced Immunosuppression Peripherally Mediated?
Summary and Future Work
SECTION II: CLINICAL STATES
Chapter 4. The Epidemiology of Opioid Bowel Dysfunction (Ysmael Yap and Marco Pappagallo)
Introduction
Gastrointestinal Adverse Effects of Opioids
Prevalence in the General Population
Prevalence in the Opioid-Treated Population
Discussion
Chapter 5. Opioid Bowel Dysfunction in Palliative Care (Nigel P. Sykes)
Introduction
Constipation
Evaluation of Constipation
Management
Nausea and Vomiting
Conclusion
Chapter 6. Opioid Bowel Dysfunction in Acute and Chronic Nonmalignant Pain (Keri L. Fakata, Ashok K. Tuteja, and Arthur G. Lipman)
Introduction
Differentiating Pain Types
Opioid Bowel Dysfunction in Acute Pain
Opioid Bowel Dysfunction in Chronic Nonmalignant Pain
Is Opioid Bowel Dysfunction Properly Addressed in These Populations?
Current Treatment Options for Opioid Bowel Dysfunction
Conclusion
Chapter 7. Postoperative Bowel Dysfunction (Cormac Fahy and Tong J. Gan)
Introduction
Pathogenesis of Postoperative Ileus
Contribution of Perioperative and Postoperative Opioids
Role of General Anesthesia in Postoperative Bowel Dysfunction
Therapy of Postoperative Bowel Dysfunction
Conclusions
Chapter 8. Postsurgical Bowel Dysfunction in the Gynecologic Patient (Eric J. Bieber)
Introduction
Pathophysiology
Bowel Function After Hysterectomy
Effect of Early Feedings and NG Use on Bowel Function
Epidurals, General Anesthesia, and Patient-Controlled Analgesia
Opioid Antagonists
Conclusion
SECTION III: ADVANCES IN TREATING OPIOID BOWEL DYSFUNCTION
Chapter 9. Using Oral Naloxone in Management of Opioid Bowel Dysfunction (Nigel P. Sykes)
Evidence for a Peripheral Site of Opioid Constipating Action
Naloxone As an Opioid Antagonist
The Use of Naloxone for Treatment of Opioid-Induced Constipation
Discussion of Reported Clinical Studies
Use of Oral Naloxone for Idiopathic Constipation
Discussion of Reported Studies of Naloxone for Idiopathic Constipation
Chapter 10. Methylnaltrexone: Investigations in Treating Opioid Bowel Dysfunction (Thomas A. Boyd and Chun-Su Yuan)
Receptor-Binding Studies
Preclinical Studies
Absorption, Elimination, and Metabolism
Safety and Tolerance Studies in Humans
Efficacy Studies
Summary
Chapter 11. Management of Opioid-Induced Bowel Dysfunction and Postoperative Ileus: Potential Role of Alvimopan (Joseph F. Foss and William K. Schmidt)
Introduction
Preclinical Development
Clinical Development
Summary
Index
Reference Notes Included
| Zusatzinfo | Illustrations |
|---|---|
| Verlagsort | Binghamton |
| Sprache | englisch |
| Gewicht | 567 g |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie |
| ISBN-10 | 0-7890-2128-5 / 0789021285 |
| ISBN-13 | 978-0-7890-2128-1 / 9780789021281 |
| Zustand | Neuware |
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