Quality of Life Assessment in Clinical Trials
Oxford University Press (Verlag)
978-0-19-262785-8 (ISBN)
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Researchers in all clinical fields are becoming increasingly aware of the importance of quality of life measurements in judging the efficacy of a given treatment, and it is becoming more common for psychological criteria to play an important role in the evaluation of therapies. In the past ten years a number of methods have been developed for carrying out such assessments. Quality of life research does however use special statistical methods which might well be unfamiliar to the clinician. "Quality of Life Assessment in Clinical Trials: Methods and Practice" explores these methods in a non-mathematical manner, comparing and contrasting the tools available to the clinician, and highlighting any potential pitfalls. It describes the methods used to collect and analyse quality of life data. The book will have widespread appeal to clinical trialists and researchers from a wide range of specialties.
Part 1 - Introduction; Understanding and using health-related QOL instruments within clinical research studies; Part 2 - Primary issues specific to quality of life trials; Guidelines for measuring health-related QOL in clinical trials; Sample sizes for randomized trials measuring QOL; Cross-cultural issues in the use of QOL measures in randomized controlled trials; Profile versus utility based measures of outcome for clinical trials; Part 3 - Decision theory and preference assessment; Introduction to decision theory and utilities; Using decision theory in clinical research: applications of QALY; Possibilities for summarizing health-related QOL when using a profile instrument; Part 4 - Psychometry; Questionnaire scaling: models and issues; Assessing reliability and validity of measurement in clinical trials; Item response theory models; Factor analysis; Part 5 - Data analysis; Methods of analysis for longitudinal studies of health-related QOL; Analysis of incomplete QOL data in clinical trials; Using the Q-Twist method for treatment comparisons in clinical trials; Part 6 - Interpreting and reporting results of QOL clinical trials; Clinical interpretation of health-related QOL data; Summarizing QOL data using graphical methods; Guidelines for reporting results of QOL assessment in clinical trials; Index
| Erscheint lt. Verlag | 5.2.1998 |
|---|---|
| Zusatzinfo | line figures, tables |
| Verlagsort | Oxford |
| Sprache | englisch |
| Maße | 168 x 240 mm |
| Gewicht | 748 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Schmerztherapie | |
| Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie | |
| ISBN-10 | 0-19-262785-6 / 0192627856 |
| ISBN-13 | 978-0-19-262785-8 / 9780192627858 |
| Zustand | Neuware |
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