Risk Assessment and Management in Cancer Genetics

Professor Evans is secretary of the UK Cancer Genetics Group. He was chairman of the UK National Institute of Clinical Excellence guidelines on familial breast cancer, Chairman of the International Collaborative Group on Familial Breast and Ovarian Cancer and on the Editorial Board of Familial Cancer. Professor Friedman is Associate Editor of the journals Genetics in Medicine and Birth Defects Research: Clinical and Molecular Teratology, and a member of the editorial board of Clinical Genetics

INTRODUCTION ; 1. How to evaluate a family history ; 2. Guidelines for referral in Europe ; 3. Guidelines for genetic counselling, testing and referral in North America ; 4. Principles and applications of gene testing for common cancers ; RISK ASSESSMENT OF COMMON MALIGNANCIES ; 5. Risk estimation in breast cancer ; 6. Risk estimation in colorectal cancer ; 7. Risk estimation in ovarian cancer ; 8a Management of familial breast and ovarian cancer in Europe ; 8b Management of familial breast and ovarian cancer in North America ; 9. Management of familial adenomatous polyposis and other inherited polyposis syndromes ; 10. Management of hereditary non-polyposis colorectal cancer ; 11. Management and risk assessment of less common familial cancers ; INHERITED CANCER SYNDROMES ; 12. The neurofibromatoses ; 13. von Hippel-Lindau disease ; 14. Multiple endocrine neoplasias ; 15. Gorlin Syndrome ; 16. The Li-Frameni Syndrome ; 17. Other tumour predisposing syndromes ; 18. The ethical and insurance issues of cancer genetics