Chronic Obstructive Pulmonary Disease

Professor Robert Stockley is the Head of Department at the Queen Elizabeth Hospital in Birmingham. He is a respiratory physician working in the field of chronic obstructive pulmonary disease. Professor Stephen Rennard is Larson Professor of Medicine in the Pulmonary and Critical Care Medicine Section of the Department of Internal Medicine at the University of Nebraska Medical Center in Omaha, Nebraska. He is the North American Editor for Respiratory Medicine and Associate Editor for COPD for the European Respiratory Journal. Professor Klaus Rabe is Professor of Pulmonary Medicine and Chairman for the Department of Pneumology in the University of Leiden. He has been active in various fields of respiratory medicine in Europe and was the first European Associate Editor of the American Journal of Respiratory and Critical Care Medicine. He is co-Chief Editor of the European Respiratory Journal. Dr Bart Celli is Professor of Medicine at Tufts University in Boston and Chief of the Division of Pulmonary and Critical Care Medicine at the St Elizabeth's Medical Center at Tufts University School of Medicine. He is the author of more than 120 publications on COPD and is the co-editor of Baum's Textbook of Pulmonary Diseases and Hodgkin's Textbook in Pulmonary Rehabilitation.

Contributors. Preface.

Section 1: Physiology.

1. Structure–Function Relationships: the Pathophysiology of Airflow Obstruction (Dennis E. Niewoehner).

2. The Physiology of Breathlessness (Donald A. Mahler).

3. The Physiology of Muscle (Ghislaine Gayan-Ramirez and Marc Decramer).

4. Exercise Limitations and Cardiopulmonary Exercise Testing in COPD (Norman R. Morris, Lewis Adams, Bruce D. Johnson and Idelle M. Weisman).

5. Clinical Assessment of Control of Breathing (Joseph Milic-Emili and Antonia Koutsoukou).

6. Physiology and Pathobiology of the Lung Circulation (Norbert F. Voelkel).

7. Sleep in Patients with COPD (Mark W. Elliott).

8. The Physiology of Cough (Marian Kollarik and Bradley J. Undem).

9. The Physiology of Gas Exchange (Robert Rodriguez-Roisin, Andrés Echazarreta, Federico P. Gómez and Joan Albert Barberà).

Section 2: COPD and Allied Conditions.

10. The Natural History of COPD (Jørgen Vestbo).

1.1 Cystic Fibrosis (Marcus P. Kennedy and Michael R. Knowles).

12. Bronchiectasis and COPD (Robert Wilson).

13. Obliterative Bronchiolitis (Hélène Levrey Hadden and Marshall I. Hertz).

14. Asthma (Diana C. Grootendorst and Klaus F. Rabe).

15. COPD: Clinical Presentation and Evaluation (Bartolome R. Celli).

16. Monitoring and Outcomes (Paul W. Jones).

Section 3: Host Defences and Inflammation.

17. Mucociliary Clearance (Souheil El-Chemaly, Adam Wanner and Matthias Salathe).

18. Mucosal Immunity (Hugues Chanteux, Charles Pilette and Yves Sibille).

19. COPD and Pulmonary Surfactant (Carola Seifart and Bernd Muller).

20. The Macrophage and its Role in the Pathogenesis of COPD (Kellie R. Jones and Jordan P. Metcalf).

21. Eosinophils and COPD (Andrew J. Wardlaw).

22. Airway Epithelial Defence, Repair and Regeneration (Christelle Coraux, Jean-Marie Tournier, Jean-Marie Zahm and Edith Puchelle).

23. The Role of the Neutrophil in the Pathogenesis of COPD (Ian S. Woolhouse and Robert A. Stockley).

24. Lymphocytes (Simonetta Baraldo, Maria Elena Zanin, Renzo Zuin and Marina Saetta).

25. Cytokines (Jack A. Elias and Robert J. Homer).

26. Leukotrienes in COPD: The Unexploited Potential (Sven-Erik Dahlén).

27. Cigarette Smoking, Emphysema and Lung Endothelium (Stephanie A. Nonas, Irina Petrache and Joe G.N. Garcia).

28. Mesenchymal Cells of the Lung (Stephen I. Rennard and J. Graham Sharp).

Section 4: Pathogenesis.

29. Lung Development (Cheng Chen, David Warburton and Wei Shi).

30. Animal Models (Piero A. Martorana, Monica Lucattelli, Barbara Bartalesi and Giuseppe Lungarella).

31. Proteinases and COPD (Anita L. Sullivan and Robert A. Stockley).

32. Oxidants (William MacNee).

33. Cigarette Smoke-Induced Disease (Stephen I. Rennard and Lisa M. Hepp).

34. COPD and Air Pollution (Kenneth Donaldson, Andrew Churg and William MacNee).

35. Viruses in COPD (Sam Hibbitts and Colin Gelder).

36. Bacteria (Sanjay Sethi).

37. Genetic Factors (Craig P. Hersh and Edwin K. Silverman).

38. α1-Antitrypsin Deficiency (Loutfi S. Aboussouan and James K. Stoller).

39. Body Weight and Systemic Effects (Emile F.M. Wouters).

40. Lung Connective Tissue (Sarah E. Dunsmore and Geoffrey J. Laurent).

Section 5: Clinical Considerations and Complications.

41. Aerosols and Delivery Systems (Stephen P. Newman).

42. Gastro-oesophageal Reflux (John K. DiBaise).

43. Upper Airway Diseases (Maria Rappai and Richard deShazo).

44. Acute Pulmonary Embolism (Victor F. Tapson).

45. COPD and Lung Cancer (Stephen G. Spiro and Frank McCaughan).

46. Infection Management and Airflow Obstruction (Alan M. Fein, Jill P. Karpel and Antonio Anzueto).

47. Mechanical Ventilation for Exacerbation of COPD (Andrea Rossi, Guido Polese and Lorenzo Appendini).

48. Comorbidity (Martin Sevenoaks and Robert A. Stockley).

Section 6: Current and Future Treatment.

49. Primary Care (Daryl Freeman and David Price).

50. Pulmonary Rehabilitation (Richard ZuWallack).

51. Social Support (Robin Stevenson).

52. Long-Term Invasive Mechanical Ventilation (Gerard J. Criner).

53. Smoking Cessation (Philip Tønnesen).

54. Oxygen Therapy in COPD (Brian Tiep and Rick Carter).

55. Surgical Therapy for COPD (Fernando J. Martinez).

56. Anticholinergics in COPD (Theodore J. Witek, Jr).

57. β2-Agonists (Malcolm Johnson).

58. Corticosteroids (Olof Selroos).

59. Phosphodiesterase 4 Inhibitors in the Treatment of COPD (Hermann Tenor, Daniela S. Bundschuh, Christian Schudt, Dirk Bredenbröker and Armin Hatzelmann).

60. Antibiotic Therapy in Patients with COPD (Michael S. Niederman).

61. Antioxidants (Claudio F. Donner).

62. Mucolytics for COPD (Duncan F. Rogers and Bruce K. Rubin).

63. End-of-Life and Palliative Care for Patients with COPD (John E. Heffner and Ann L. Heffner).

64. Economic Burden of COPD (David H. Au and Sean D. Sullivan).

65. Pharmacoepidemiology of COPD (Joan B. Soriano).

66. Social and Behavioural Impact of COPD – Research Opportunities (Suzanne S. Hurd and Claude Lenfant).

67. Guidelines (Peter M.A. Calverley).

Section 7: Pharmacotherapy: Developing Therapies.

68. Protease Inhibitors (Philip Davies, Malcolm MacCoss and Richard Mumford).

69. Retinoids (Stephen R. Tudhope).

70. Chemokines in COPD (Peter J. Barnes).

Index.