Diabetes mellitus is one of the major causes of morbidity and mortality in the modern world. Persistent hyperglycaemia is responsible for several complications of diabetes, such as diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, diabetic cardiomyopathy, diabetic autonomic neuropathy, diabetic ketoacidosis, diabetic foot ulcer, gestational diabetes, and diabetic mastopathy. With the advancement of technology, several new drugs have been developed for treatment of diabetes and diabetic complications. Moreover, alternative and complementary medicines have also been employed to manage diabetes and its associated complications. Despite the availability of a plethora of therapeutic agents, the management of diabetes and diabetic complications is an uphill battle associated with several limitations. Various leading research groups across the world are investing billions of dollars to develop impeccable solutions for the treatment of diabetes and diabetic complications. This book focuses on the understanding of recent advancements in the pathogenesis of diabetes and diabetic complications, the molecular basis of the disease and recent advancements in diabetic treatment. The chapters are specifically dedicated to different complications associated with diabetes. Moreover, recent advances in treatments and medications in clinical trials for these complications are explained. Some chapters are dedicated to the use of herbal medicines, alternative and complementary therapy and personalized medicines. Furthermore, the role of epigenetics in diabetic complications is described, as well as the role of antidiabetic drugs and their interactions. Due to its widespread prevalence, diabetes is presently considered a pandemic. This book provides contemporary information to researchers and health care practitioners about diabetes and diabetic complications, which may pave the way for designing new strategies to manage diabetes and diabetic complications. Moreover, the insights on alternative and complementary medicines will help in providing a background for inclusion of these medicines as an important therapeutic option for treatment of diabetes.
Randhir Singh Dahiya Professor, M M College of Pharmacy, Maharishi Markandeshwar University, Ambala, India
Preface; Comprehending Type-I Diabetes Mellitus; Comprehending Type-II Diabetes Mellitus; Diabetes and Diabetic Complications: Current Status and Future Prospective; Molecular Basis of Diabetic Nephropathy; Diabetic Neuropathy: Pathogenesis and Therapeutic Management; Diabetic Retinopathy: Pathogenesis and Therapeutic Management; Diabetic Cardiomyopathy: Pathophysiological Mechanisms and Potential Target Sites; Diabetic Mastopathy: Pathogenesis and Therapeutic Management; Diabetic Foot Ulcer: Pathogenies and Treatment Strategies; Diabetic Ketoacidosis: Pathogenesis and Treatment; Diabetic Autonomic Neuropathy: Pathogenesis and Treatment; The Role of Epigenetic in Complications of Diabetes-Mellitus; Role of Oxidative Stress and Inflammation in Complications of Diabetes; Diabetes in Pregnancy Gestational Diabetes Mellitus; Novel Pharmacological Approaches for Diabetic Complications; Personalized Medicine for Management of Diabetic Complications; Pharmacokinetics of Antidiabetic Drugs and Their Interactions; Diabetic Complications and Non-Conventional Therapies; Drugs in Clinical Research for Management of Diabetic Complications; Herbal Approach in Management of Diabetes and Its Complications; Quality of Life (QoL) in Diabetes Mellitus; Index.
