Clinical Pharmacology During Pregnancy

Dr. Mattison also serves as Associate Director of the McLaughlin Centre for Population Health Risk Assessment at the University of Ottawa. He has held academic, clinical and research appointments, including; Senior Advisor to the Director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Medical Director of the March of Dimes; Dean of the Graduate School of Public Health at the University of Pittsburgh, Professor of Obstetrics and Gynecology and Interdisciplinary Toxicology at the University of Arkansas for Medical Sciences, and Director of Human Risk Assessment at the FDA National Center for Toxicological Research. Dr. Mattison earned a BA (Chemistry and Mathematics) from Augsburg College in Minneapolis, MN, an MS (Chemistry) from the Massachusetts Institute of Technology, Cambridge, MA and a MD from the College of Physicians and Surgeons, Columbia University, New York, NY. His clinical training in Obstetrics and Gynecology was at the Sloane Hospital for Women in the Columbia Presbyterian Medical Center in New York. His training in Pharmacology and Toxicology was at the National Institutes of Health, Bethesda, MD. In 1997, he was elected a Fellow of the American Association for the Advancement of Science, in 1999, a Fellow of the New York Academy of Medicine, in 2000 a member of the Institute of Medicine, in 2005 Distinguished Alumni of Augsburg College and in 2009 a Fellow of the Royal Society of Medicine. Dr. Lee-Ann Halbert, EdD, JD, RN, MSN, NCSN, CNM, CNE, an Associate Professor of Nursing, is a member of the faculty at the University of South Carolina Beaufort. Dr. Halbert came to the field of Nursing after finding practicing as an attorney was unfulfilling. In her time as a nurse, Dr. Halbert has focused on women’s health, in particular practicing as a Certified Nurse-Midwife, and school nursing.

1. Introduction 2. Physiologic Changes During Pregnancy 3. Impact of Pregnancy on Maternal Pharmacokinetics of Medications 4. Medications and the Breastfeeding Mother 5. Fetal Drug Therapy 6. Treating the Placenta: An Evolving Therapeutic Concept 7. What is Sufficient Evidence to Justify a Multicenter Phase 3 Randomized Controlled Trial in Obstetrics? 8. Ethics of Clinical Pharmacology Research in Pregnancy 9. Pharmacogenomics in Pregnancy 10. Analgesics and Anti-Inflammatory, General and Local Anesthetics and Muscle Relaxants 11. The Management of Asthma During Pregnancy 12. Updated Guidelines for the Management of Nausea and Vomiting of Pregnancy 13. Clinical Pharmacology of Anti-Infectives During Pregnancy 14. Chemotherapy in Pregnancy 15. Substance Use Disorders 16. Diabetes in Pregnancy 17. Cardiovascular Medications in Pregnancy 18. Antidepressants in Pregnancy 19. Uterine Contraction Agents and Tocolytics 20. Antenatal Thyroid Disease and Pharmacotherapy in Pregnancy 21. Dermatological Medications and Local Therapeutics 22. Vitamins, Minerals, Trace Elements, and Dietary Supplements 23. Herbs and Alternative Remedies 24. Envenomations and Antivenoms During Pregnancy 25. Gastrointestinal Disorders