Neuroprotective Agents and Cerebral Ischaemia

Professor Peter Jenner is a specialist in preclinical aspects of neurodegenerative diseases, notably Parkinson’s disease. He has spent the major part of his career at King’s College London where he was Head of Pharmacology for 14 years before returning to his research roots and subsequently becoming Emeritus Professor of Pharmacology. Peter has expertise in drug metabolism and pharmacokinetics but neuropharmacology based on functional models of neurodegenerative diseases has formed the major focus of his work. Peter holds a BPharm, PhD and DSc degree from the University of London. He has published well over 1000 articles with more than 700 peer reviewed papers. He is a Fellow of the Royal Pharmaceutical Society, the British Pharmacological Society, the Royal Society of Medicine and of King’s College London. Peter was recently honoured with a Doctor Honoris Causa degree from Carol Davila University of Medicine and Pharmacy, Bucharest and made an Honorary Fellow of The British Pharmacological Society for his contribution to research in to movement disorders. Peter has worked closely with the pharmaceutical industry for many years and acts as an adviser and consultant to both major pharma and biotech companies. He has a wide knowledge of the drug discovery and drug development process and has been involved from molecule synthesis through to drug registration for use in man. Peter was the Founder, Director and Chief Scientific Officer of Proximagen, a biotech focussed on the treatment and cure of neurodegenerative diseases that was listed on AIMs and subsequently purchased by a US based healthcare company. He is a regular speaker at international meetings and also takes time to speak at Parkinson’s disease patient-carer groups across the UK. Alan Cross was at the MRC Clinical Research Centre, London, followed by two years as a lecturer in the Department of Physiology, University of Manchester. In 1980 he became Head of Pharmacology at the Aston Neuroscience Research Unit.

Mechanisms of Nerve Cell Death: Apoptosis or Necrosis after Cerebral Ischaemia, R.M.E. Chalmers-Redman, A.D. Fraser, W.Y.H. Ju, J. Wadia, N.A. Tatton, and W.G. Tatton.
Changes in Ionic Fluxes during Cerebral Ischaemia, T. Kristián and B.K. Siesjö.
Techniques for Examining Neuroprotective Drugs in Vivo, A.R. Green and A.J. Cross.
Techniques for Assessing Neuroprotective Drugs in Vitro, M. P. Goldberg, U. Strasser and L.L. Dugan.
Calcium Antagonists: Their Role in Neuroprotection, A.J. Hunter.
Sodium and Potassium Channel Modulators: Their Role in Neuroprotection, T.P. Obrenovich.
NMDA Antagonists: Their Role in Neuroprotection, D.L. Small and A.M. Buchan.
Development of the NMDA Ion-Channel Blocker Aptiganel Hydrochloride as a Neuroprotective Agent for Acute CNS Injury, R.N. McBurney.
Pharmacology of AMPA Antagonists and their Role in Neuroprotection, R. Gill and D. Lodge.
GABA and Neuroprotection, P.D. Lyden.
Adenosine and Neuroprotection, B.B. Fredholm.
Interleukins and Cerebral Ischaemia, N.J. Rothwell, S.A. Loddick, and P. Stroemer.
Nitrone-Based Free Radical Traps as Neuroprotective Agents in Cerebral Ischaemia and other Pathologies, K.Hensley, J.M. Carney, C.A. Stewart, T. Tabatabaie, Q. Pye, and R.A. Floyd.
Neurotoxic and Neuroprotective Roles of Nitric Oxide in Cerebral Ischaemia, T. Dalkara and M.A. Moskowitz.
A Review of Earlier Clinical Studies on Neuroprotective Agents and Current Approaches, N.G. Wahlgren.
Index.
Contents of Recent Volumes.