Homocysteine in Health and Disease

1. Introduction: historical overview and recent perspectives David Wilken and Bridget Wilken; Part I. Biochemistry and Physiology; Section I. Chemistry: 2. Practical chemistry of homocysteine and other thiols Donald W. Jacobsen; 3. Biosynthesis and reactions of homocysteine thiolactone Hieronim Jakubowski; 4. Homocysteine and lipid oxidation Jay W. Heinecke; 5. Homocysteine, nitric oxide and nitrosothiols Andrew J. Gow, Fred Cobb and Jonathan S. Stamler; Section II. Biochemistry and metabolism: 6. Biosynthesis of S-adenosylmethionine Jose M. Mato, Matias A. Avila and Fernado J. Corrales; 7. S-adenosylmethionine-dependent methyltransferase Steven G. Clarke and Kelly Banfield; 8. S-adenosylhomosysteine hydrolase Sean T. Prigge and Peter K. Chiang; 9. Regulation of homocysteine metabolism James D. Finkelstein; 10. Microbial modeling of human disease: homocysteine metabolism Rowena G. Matthews and Martha L. Ludwig; 11. Folate metabolism Robert J. Cook; 12. Cobalamin-dependent remethylation Ruma V. Banerjee and Horatiu Olteanu; 13. Betaine-dependent remethylation Tim Garrow; 14. The transsulfuration pathway Warren D. Kruger; Section III. Physiology: 15. Cellular transport and tissue distribution Brian Fowler; 16. Homocysteine and the kidney John T. Brosnan; 17. Homocysteine and the nervous system Anne M. Molloy and Donald G. Weir; Section IV. Clinical Chemistry: 18. Methodologies of testing Karsten Rasmussen and Jan Möller; 19. Methionine loading Nicholas Dudman and Jonathan Silberberg; Part II. Clinical Dysfunction and Hyperhomocysteinemia; Section V. Genetic Disorders: 20. Cystathionine-ß-synthase and its deficiency Jan P. Kraus and Viktor Kozich; 21. Inborn errors of folate and cobalamin metabolism David S. Rosenblatt; 22. Polymorphisms of folate and cobalamin metabolism Rima Rozen; Section VI. Acquired Disorders: 23. Folate deficiency Ralph Carmel; 24. Cobalamin deficiency Ralph Carmel; 25. Vitamin B6 deficiency Jesse F. Gregory III; 26. Homocysteine in renal disease Margret Arnadottir and Björn Hultberg; 27. Diseases and drugs associated with hyperhomocysteinemia Henk J. Blom; 28. Lifestyle factors associated with hyperhomocysteinemia Stein Emil Vollset, Helga Refsum, Ottar Nygard and Per Ueland; Section VII. Clinical Consequences of Hyperhomocysteinemia: 29. Epidemiology: vascular and thrombotic associations Petra Verhoef and Meir Stampfer; 30. Homocysteine and coronary artery disease Killian Robinson; 31. Homocysteine and cerebrovascular disease J. David Spence and James F. Toole; 32. Peripheral arterial disease Godfried Boers; 33. Venous disease Armando D'Angelo and Chiara Beltrametti; 34. Homocysteine and hemostasis Katherine A. Hajjar; 35. Cellular mechanisms of homocysteine pathogenesis in atherosclerosis Donald W. Jacobsen; 36. Homocysteine and cardiovascular physiology Steven R. Lentz; 37. Homocysteine and human reproduction T. K. A. B. Eskes; Section VIII. Intervention and Therapy: 38. Modification of hyperhomocysteinemia John M. Scott; 39. Design of clinical trials to test the homocysteine hypothesis of vascular disease Robert Clarke; 40. What is a desirable homocysteine level? Johan B. Ubbink; Index.