Drug-Induced Liver Injury

Anup Ramachandran is at University of Kansas Medical Center, KS, USA Dr. Hartmut Jaeschke, PhD, is the University Distinguished Professor and Chairman of the Department of Pharmacology, Toxicology, and Therapeutics at the University of Kansas Medical Center, Kansas City, Kansas. He joined KUMC in 2006. He is a Fellow of the Academy of Toxicological Sciences and Fellow of the American Association for the Study of Liver Diseases. He has published more than 470 peer-reviewed manuscripts, invited reviews, and book chapters in the areas of liver toxicology and liver pathophysiology. He currently serves as an Associate Editor for Toxicological Sciences, the inaugural Editor-in-Chief of Livers (since 2020), and is a member of 14 editorial boards. In 2019, he was the recipient of the Translational Impact Award from the Society of Toxicology. His major research interests include basic mechanisms and translational aspects of xenobiotic-induced hepatotoxicity and tissue repair with a focus on acetaminophen overdose and mechanisms of inflammatory liver injury in animal models and humans.

1. Primary hepatocytes and their cultures for the testing of drug-induced liver injury Vânia Vilas-Boas, Axelle Cooreman, Eva Gijbels, Raf Van Campenhout, Emma Gustafson, Steven Ballet, Pieter Annaert, Bruno Cogliati and Mathieu Vinken 2. Cell death in drug-induced liver injury Andrea Iorga and Lily Dara 3. Drug-induced liver injury in obesity and nonalcoholic fatty liver disease Julien Allard, Dounia Le Guillou, Karima Begriche and Bernard Fromenty 4. Role and mechanisms of autophagy in alcohol-induced liver injury Xiaojuan Chao and Wen-Xing Ding 5. Mechanisms of idiosyncratic drug-induced liver injury Jack Uetrecht 6. Idiosyncratic drug-induced liver injury in patients: detection, severity assessment, and regulatory implications Paul B. Watkins 7. Acetaminophen hepatotoxicity: A mitochondrial perspective Anup Ramachandran and Hartmut Jaeschke 8. Biomarkers of drug-induced liver injury Mitchell R. McGill and Hartmut Jaeschke 9. Mechanisms and biomarkers of liver regeneration after drug-induced liver injury Melissa M. Clemens, Mitchell R. McGill and Udayan Apte 10. Evaluation and treatment of acetaminophen toxicity Erik S. Fisher and Steven C. Curry