Malignant Brain Tumors

State-of-the-Art Treatment

Jennifer Moliterno Gunel, Joseph M Piepmeier, Joachim M. Baehring (Herausgeber)

Buch | Softcover

XI, 297 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-84259-2 (ISBN)

Artikel merken

This text addresses all aspects of patient evaluation and care. This includes new findings in imaging that provide a better understanding of the extent of the lesion as well as its relationship with critical neuroanatomic function. The evolution of intraoperative imaging, functional brain mapping,and technology to identify tumor from brain is covered. This has significantly improved the ability of surgeons to more safely and aggressively remove tumors.More importantly, a better understanding of tumor biology and genomics has created an opportunity to significantly revise tumor classification and better select optimal therapy for individual patients. The text covers novel and innovative treatment options including immunotherapy, tumor vaccines, antiangiogenic agents,and personalized cancer treatment. In addition, novel agent delivery techniques are covered to offer the potential for increasing the effectiveness of treatment by delivering active agents directly where they areneeded most.
Malignant Brain Tumors: State-of-the-Art Treatment provides a comprehensive overview of treatment for malignant gliomas, and will prove useful by updating physicians on new therapeutic paradigms and what is on the horizon for the near future. This text will be informative for surgeons, oncologists, neurologists, residents and students who treat these patients,as well as those who are training for a career in managing patients with these challenging tumors.

Joseph M Piepmeier, MDNixdorff-German Professor of NeurosurgeryDepartment of NeurosurgeryYale University School of MedicineNew Haven, ConnecticutUSA Jennifer Moliterno Gunel, MDAssistant Professor, Department of NeurosurgerySection of Neurosurgical OncologyYale University School of MedicineNew Haven, ConnecticutUSA Joachim M. Baehring, MD, DSc.Department of Neurology and NeurosurgeryYale University School of MedicineNew Haven, ConnecticutUSA

Part I: Molecular and Clinical Characterization of Gliomas.- The Use of Advanced Neuro-Imaging (fMRI, DTI/Tractography) in the Treatment of Malignant Gliomas.- Molecular Neuropathology and the Ontogeny of Malignant Gloimas.- Personalized Medicine through Advanced Genomics.- Part II: Surgery: Maximizing the Extent of Tumor Resection.- The Usefulness of Stereotactic Neuronavigation Along with Intraoperative Imaging in Malignant Brain Tumor Surgery.- Mapping the Brain for Primary Tumor Surgery.- Fluorescence-guided Resection of Malignant Gliomas.- The Rolse of Laser-Induced Thermal Therapy in the Management of Malignant Gliomas.- Part III: Adjuvant Therapies.- Current Standard Treatment Options of Malignant Glioma.- Targeting Aberrant Signaling Pathways.- Targeted Therapy of IDH1-mutated Tumors.- Antiangiogenic Therapy for Malignant Gliomas.- Immunotherapy for High-Grade Gliomas.- Novel Delivery Strategies.- Radiation Therapy for Malignant Gliomas: Current Options.- Glioma Radiosensitizers: Exciting New Developments and Directions.- Part IV: Tumor-Specific Approach: Oligodendroglioma (IDH1 mutated, 1p/19q deleted).- Glioblastoma.

"This textbook analyzes the dismal prognosis and very limited efficacy for single or multi agent therapy of Glioblastomas GBMs. ... I recommend this book to neurosurgeons and oncologists" (Joseph Grenier, Amazon.de, May, 2018)

"This succinct book is designed as a comprehensive, yet concise update on the contemporary treatment of gliomas. ... The audience includes neurosurgeons, neurologists, oncologists, and all practitioners with routine exposure to gliomas. ... This is a satisfactory update on the contemporary biology and treatment for neuro-oncology's enduring foe: gliomas. ... The book provides a succinct, effective research update for clinicians wishing to familiarize themselves with advances in the field over the last decade." (Darian Ross Esfahani, Doody's Book Reviews, April, 2017)

Erscheint lt. Verlag	7.7.2018
Zusatzinfo	XI, 297 p. 49 illus., 43 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	178 x 254 mm
Gewicht	809 g
Themenwelt	Medizinische Fachgebiete ► Chirurgie ► Neurochirurgie
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Schlagworte	Antiangiogenic Therapy • Biology of Gliomas • Fluorescence-guided resection • Glioblastoma multiforme • intraoperative imaging • neuro-imaging • Oligodendroglioma • surgical oncology
ISBN-10	3-319-84259-5 / 3319842595
ISBN-13	978-3-319-84259-2 / 9783319842592
Zustand	Neuware