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Five-Lipoxygenase Products in Asthma

Jeffrey Drazen (Herausgeber)

Buch | Hardcover
496 Seiten
1998
Crc Press Inc (Verlag)
978-0-8247-0167-3 (ISBN)
133,40 inkl. MwSt
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Offers an examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma. This book explores the enzymology of the 5-LO pathway with focus on leukotriene transport, degradation, and excretion. It is for respiratory therapists; physiologists; pathologists; and others.
Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma.
A critical reference for every asthma researcher and clinician, Five-Lipoxygenase Products in Asthma
highlights agents and products of the 5-LO pathway and its relationship to other pathways

explores the enzymology of the 5-LO pathway with focus on leukotriene transport, degradation, and excretion

details the role of protein identification in the 5-LO pathway

describes human cell types that produce leukotrienes and their activation

outlines pharmacological and binding study evidence for leukotriene receptors

discusses the recovery of leukotrienes in lung disease

analyzes leukotriene receptor antagonists and synthesis inhibitors by specific agent

provides a by entity summary of individual drug information in exercise-induced, allergen-induced, aspirin-induced, and chronic stable asthma

profiles the use of agents active on the 5-LO pathway in asthma treatment

and more!
With complete discussions of the recovery of leukotrienes in induced and spontaneous asthma and other conditions, Five-Lipoxygenase Products in Asthma, will benefit pulmonologists and pulmonary disease specialists; clinical allergists; internists; chest, intensive care, primary care, and family practice physicians; respiratory therapists; physiologists; pathologists; cell and molecular biologists; and graduate and medical school students in these disciplines.

Overview

Overview of the 5-Lipoxygenase Pathway, Jesper Z. Haeggström and Bengt Samuelsson

Leukotriene Biochemistry

5-Lipoxygenase and 5-Lipoxygenase-Activating Protein, Jilly F. Evans
Leukotriene C4 Synthase: A Pivotal Enzyme in the Biosynthesis of Cysteinyl Leukotrienes, John F. Penrose and K. Frank Austen
Leukotriene A4 Hydrolase, Jesper Z. Haeggström
Leukotriene Export in Human Leukocytes, Bing K. Lam

Cell Biology of the Leukotrienes

Pathways of Leukotriene Metabolism in Isolated Cell Models and Human Subjects, Robert C. Murphy and Pat Wheelan
Cell Biology of the 5-Lipoxygenase Pathway: Amplification and Generation of Leukotrienes and Lipoxins by Transcellular Biosynthesis, Timothy D. Bigby, Bruce D. Levy, and Charles N. Serhan

Physiological Actions of the Leukotrienes

Leukotriene Receptors: Incompletely Defined Targets for Treatment of Asthma and Inflammation, Sven-Erik Dahlén
Physiological Effects of the Leukotrienes in Humans, Neil C. Barnes and Lewis J. Smith

Recovery of Leukotrienes

Analysis of Leukotrienes and Lipoxins, Graham W. Taylor
Measurement of Leukotrienes from Human Biological Fluids, Jay Y. Westcott and Ian K. Taylor

Leukotrienes in Asthma

Cysteinyl-Leukotriene Receptor Antagonism and 5-Lipoxygenase Inhibition in Asthma, S. M. Shuaib Nasser and Tak H. Lee
Leukotriene Receptor Antagonism and Synthesis in Chronic Stable Asthma, Elliot Israel and Jeffrey M. Drazen

Specific Drug Products

Montelukast-An Antileukotriene Treatment for Asthma: Changing the Asthma-Treatment Paradigm, Beth C. Seidenberg and Theodore F. Reiss
Pranlukast-The First Orally Active Cysteinyl Leukotriene Receptor Antagonist Marketed for the Treatment of Asthma, Jeffrey W. Dubb and Anthony S. Rebuck
Zafirlukast, Catherine M. Bonuccelli and Trevor J. C. Higgins
Zileuton: The First Leukotriene Synthesis Inhibitor for Use in the Management of Chronic Asthma, Louise M. Dubé, Linda J. Swanson, Walid Awni, Rachel F. Ochs, Randy L. Bell, and George W. Carter
Antileukotrienes in the Management of Asthma, Paul M. O'Byrne

Reihe/Serie Lung Biology in Health and Disease
Verlagsort Bosa Roca
Sprache englisch
Maße 216 x 279 mm
Gewicht 816 g
Themenwelt Medizinische Fachgebiete Innere Medizin Pneumologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
ISBN-10 0-8247-0167-4 / 0824701674
ISBN-13 978-0-8247-0167-3 / 9780824701673
Zustand Neuware
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