Resistance to Ibritumomab in Lymphoma

Makoto Hosono, MD, PhD, is a Professor of Radiology and Nuclear Medicine, Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine, Japan, and serves as a member of Committee 3, International Commission on Radiological Protection. Jean-François Chatal, MD, PhD, is an Emeritus Professor of Nuclear Medicine at the University of Nantes, France. He is one of the international leaders who developed radioimmunotherapy, that is, therapy using radiolabeled anti-tumor antibodies. He created and headed an INSERM research laboratory and also initiated the installation of a cyclotron institute termed ARRONAX for the production of novel radionuclides for nuclear medicine.

Clinical Use and Efficacy of Ibritumomab in B-cell Lymphoma.- Biology and Pathology of B-cell lymphoma.- Resistance to Y-90 Ibritumomab Tiuxetan Therapy.- Features of Ibritumomab as Radionuclide Therapy.- Radiological Evaluation of Response and Resistance of Ibritumomab.- Characteristics of Ibritumomab as Radionuclide Therapy Agent.- Resistance and Heterogeneity of Intratumoral Antibody Distribution.- Radiation Dosimetry in Ibritumomab Therapy.- Combining RAIT and immune-based therapies to overcome resistance in cancer?.- Prospects for enhancing efficacy of radioimmunotherapy.- Index.