Pediatric Inflammatory Bowel Disease

Petar Mamula, MD Associate Professor of Pediatrics, The Children's Hospital of Philadelphia, Division of GI, Hepatology & Nutrition, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Andrew B. Grossman, MDCo-Director, Center for Pediatric Inflammatory Bowel Disease, The Children's Hospital of Philadelphia, Division of GI, Hepatology & Nutrition , Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USARobert N. Baldassano, MD Director, Center for Pediatric Inflammatory Bowel Disease, The Children's Hospital of Philadelphia, Division of GI, Hepatology & Nutrition, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA< USAJudith R. Kelsen, MD The Children's Hospital of Philadelphia, Division of GI, Hepatology & Nutrition, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USAJonathan E. Markowitz, MD, MSCE Clinical Professor of Pediatrics, University of South Carolina School of Medicine - Greenville Chief, Division of Pediatric Gastroenterology & Nutrition, Greenville Health System, Greenville, SC, USA 

lt;p>Section I Etiology and Pathogenesis

1 Genetics of Inflammatory Bowel Diseases

Christopher J. Cardinale, Hakon Hakonarson

2 The Intestinal Immune System During Homeostasis and Inflammatory Bowel Disease

David A. Hill, William A. Faubion Jr.

3 Cytokines and Inflammatory Bowel Disease

Edwin F. de Zoeten, Ivan J. Fuss

4 The Gut Microbiota and Inflammatory Bowel Disease

Máire A. Conrad, Gary D. Wu, Judith R. Kelsen

5 Immune Dysregulation Associated with Very Early-Onset Inflammatory Bowel Disease

Judith Kelsen, Kathleen Sullivan

Section II Epidemiology and Clinical Features

6 Epidemiology of Pediatric Inflammatory Bowel Disease

Shehzad Saeed, Subra Kugathasan

7 The Natural History of Crohn Disease in Children

Benjamin Sahn, James Markowitz

8 Natural History of Ulcerative Colitis in Children

9 Natural History of Pediatric Indeterminate Colitis

Melissa A. Fernandes, Sofia Verstraete, Melvin B. Heyman

10 Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease

Shervin Rabizadeh, Maria Oliva-Hemker

11 Liver Disease in Pediatric Inflammatory Bowel Disease

Amanda Ricciuto, Binita M. Kamath

12 Growth Impairment in Pediatric Inflammatory Bowel Disease

Thomas D. Walters, Anne M. Griffiths

13 Inflammatory Bowel Diseases and Skeletal Health

Francisco Sylvester

14 Puberty and Pediatric-Onset Inflammatory Bowel Disease

Dianne Deplewski, Neera Gupta, Barbara S. Kirschner

15 Classification of Inflammatory Bowel Disease in Children

Mary E. Sherlock, Eric I. Benchimol

Section III Diagnosis

16 The History and Physical Exam

Alka Goyal

17 Differential Diagnosis of Inflammatory Bowel Disease

Thierry Lamireau, Raphael Enaud

18 Laboratory Evaulation of Inflammatory Bowel Disease

Jennifer Strople, Benjamin D. Gold

19 Fecal Biomarkers in Inflammatory Bowel Disease

Jennifer Damman, KT Park

20 Radiologic Evaulation of Pediatric Inflammatory Bowel Disease

Stephen M. Druhan, Benedict C. Nwomeh

21 Endoscopy and Inflammatory Bowel Disease

Shishu Sharma, Krishnappa Venkatesh, Mike Thomson

22 The Pathology of Chronic Inflammatory Bowel Disease

Pierre Russo

23 Video Capsule Endoscopy in Inflammatory Bowel Disease

Ernest G. Seidman, Che Yung Chao, Ana Maria Sant'Anna

24 Bone Health in Pediatric Inflammatory Bowel Disease

Dale Lee, Edisio Semeao

Section IV Medical Therapy

25 5-Aminosalicylate Therapy

Michael Stephens, Michelle Gonzalez

26 Antibiotic Therapy

Lindsey Albenberg, Howard Kader, Adam Paul

27 Nutritional Management of Inflammatory Bowel Disease

Anthony Otley, Andrew Day, Mary Zachos

28 Probiotic Therapy

David R. Mack

29 Corticosteroids

Charles M. Samson, Johanna C. Escher

30 6-Mercaptopurpine Therapy

Carmen Cuffari

31 Methotrexate

Joel R. Rosh

32 Infliximab Therapy for Pediatric Crohn Disease and Ulcerative Colitis

Philip Minar, Dana Dykes, Ana Catalina Arce-Clachar, Shehzad A. Saeed

33 Anti-TNF Biologic Therapies Other Than Infliximab

Calen A. Steiner, Emily P. Whitfield, Jeremy Adler, Peter D.R. Higgins

34 Therapeutic Drug Monitoring in Pediatric Inflammatory Bowel Disease

Namita Singh, Marla C. Dubinsky

35 New Non-anti-TNF Therapies for the Treatment of Inflammatory Bowel Disease

36 Medical Treatment of Perianal Crohn's Disease Fistulae

Mark T. Osterman, Gary R. Lichtenstein

37 Treatment of Acute Severe Ulcerative Colitis

Jess L. Kaplan, Harland S. Winter

38 Dietary Therapies for Inflammatory Bowel Disease

Ronen Stein, Robert N. Baldassano

39 Complementary and Alternative Therapies

Jennifer Panganiban, Jessi Erlichman, Maria Mascarenhas

Section V Surgical Considerations

40 Management of Intraabdominal Complications of Inflammatory Bowel Disease

Elizabeth C. Maxwell, Peter Mattei, Andrew B. Grossman

41 Surgical Management of Crohn Disease in Children

Daniel von Allmen

42 Surgical Treatment of Ulcerative Colitis

Peter Mattei

43 Postoperative Surveillance and Management of Crohn's Disease

Arthur M. Barrie III, Miguel Regueiro

44 Pouchitis After Ileal Pouch-Anal Anastomosis

Jacob Kurowski, Marsha Kay, Robert Wyllie

45 Enteral Feeding Devices and Ostomies

Judith J. Stellar

Section VI Research

46 Clinical Indices for Pediatric Inflammatory Bowel Disease Research

Dan Turner, Oren Ledder

47 Clinical Trials (Clinical Perspective)

Salvatore Cucchiara, Marina Aloi

48 Clinical Trials (Industry/Regulatory Perspective)

Tara Altepeter, Kurt Brown, Peterson Johnson, Andrew E. Mulberg

Section VII Special Considerations

49 Infectious Complications of Pediatric Inflammatory Bowel Disease

Monica I. Ardura, Sandra C. Kim

50 Psychological Aspects of Inflammatory Bowel Disease in Children and Adolescents

Bonney Reed-Knight, Laura M. Mackner, Wallace V. Crandall

51 Measurement of Quality of Life in Pediatric Inflammatory BOwel Disease

Amy Grant, Anthony Otley

52 Irritable Bowel Syndrome and Functional GI Disorders in Inflammatory Bowel Disease

Khalil I El-Chammas, Manu R. Sood

53 Inflammatory Bowel Disease in Pregnancy

Sunanda Kane

54 Immunizations in the Child with Inflammatory Bowel Disease

Athos Bousvaros, Ying Lu

55 Malignant Tumors Arising in Inflammatory Bowel Disease

Thomas A. Ullman, Rona Yaeger

56 Quality Improvement in Inflammatory Bowel Disease

Jeremy Adler, Richard B. Colletti, Wallace V. Crandall, Peter A. Margolis

57 Fostering Self-Management and Patient Activation

David Alain Wohl, Justin Vandergrift

58 Advocacy for Pediatric Patients with Inflammatory Bowel Disease

Janis Arnold, Athos Bousvaros

59 Legislative Advocacy

Sarah Buchanan, Suzanne Rosenthal

60 Transition from Pediatric to Adult Care

Stacy A. Kahn, Sandra C. Kim

"This book is intended for all practitioners who care for or are involved in the care of these complex patients. ... this book provides clinically applicable information for primary care providers to pediatric subspecialists. ... This is an excellent resource. The editors have done a great job of recruiting a group of authors who are leaders in this field and have organized the book in a logical and progressive fashion." (Vincent Biank, Doody's Book Reviews, September, 2017)