Chemical Biology of Nucleic Acids

RNA as Major Components in Chemical Evolvable Systems.- How the Early Genetic Code Was Established? - Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems.- Isomerization of RNA Phosphodiester Linkages.- Effects of Ionic Liquid and Liposomes on the Structure, Stability and Function of Nucleic Acids.- Oxidative Damage on RNA Nucleobases.- Use of FRET to Study Dynamics of DNA Replication.- Design, Characterization and Application of Imidazopyridopyrimidine:Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds.- Creation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies.- Flexible Nucleobase Analogues. Novel Tools for Exploring the Nucleic Acids.- Sequence Selective Recognition of Double-Stranded RNA.- Determining Transient Nucleic Acid Structures by NMR.- Diastereomer-Specific Repertoire of 7'R- or 7'S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physicochemical and Enzymological Properties.- Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms.- Progress in Chemically Modified Nucleic Acid Aptamers.- Aptamers as Molecular Smugglers.- Biochemical Aspects of Subcellular RNA Transport and Localization.- Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications.- Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology.- Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges.- Interaction of DNA Intramolecular Structures with Their Complementary Strands: A Thermodynamic Approach for the Control of Gene Expression.- Site Directed Spin Labelling of RNA for Distance Measurements by EPR.- Chemo-Enzymatic Strategies to Modify RNA in vitro or in Living Cells.- Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ1 Riboswitches.- DNA G-Quadruplexes and I-Motifs in Therapeuticsand Diagnostics.- Peptides Targeting G-Quadruplex Structures.- Synthesis of Site-Specifically Modified Long-Mer RNAs.- Synthesis and Exon-Skipping Activity of Chemically-Modified RNAs.- mRNA and snRNA Cap Analogs: Synthesis and Applications.- Innovative Chemistry for Synthesis of Regular RNA, 5'-Triphosphate RNA or 5'-Capped RNA.