Short-term Toxicity Tests for Non-genotoxic Effects

Part 1 Joint report: introduction, general conclusions and recommendations; non-specialized Mammalian cell cultures for toxicity testing; test methods to detect toxic effects in specific Mammalian organs and physiological systems; methods to predict toxicity; short-term tests in ecotoxicology. Part 2 Contributed papers: conceptual approaches to methodology development, Alan M.Goldberg and Andrew N.Rowan; toxicity tests with Mammalian cell cultures, B.Ekwall et al; the gastrointestinal tract and short-term toxicity tests, Donald Barltrop and Martin J.Brueton; specific organ/system toxicity - the liver, James W.Bridges; the developing kidney in toxicity tests, Lauri Saxen; the skin - predictive value of short-term toxicity tests, Raymond R.Suskind; evaluation and prediction of chemical toxicity using haematopoietic cell renewal systems, T.M.Fliedner et al; short-term tests for neurotoxicity, Silvio Garattini; methods for assessing the effects of chemicals on the endocrine system, J.H.Clark and F.X.R.van Leeuwen; methods for assessing the effects of chemicals on the immune system, J.G.Vos and J.H.Dean; potential short-term tests to detect chemicals capable of causing reproductive and developmental dysfunction, Carlton H.Nadolney et al; toxicological versus ecotoxicological testing, Guido Persoone and James Gillett; possibilities and limitations of predictions from short-term tests in the aquatic environment, Guido Persoone et al; possibilities and limitations of short-term tests for ecotoxicologic effects - terrestrial approaches, James W.Gillett; predicting safe levels of chemicals, I.V.Sanockij; computer aided chemical structure-handling techniques in structure-activity relations, Josef Friedrich et al.