Oral Delivery of Insulin

T. A. Sonia is a doctoral student working in the field of development of polymeric nano/micro particles for oral delivery of insulin under the guidance of Dr Chandra P Sharma at Biosurface Technology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Science & Technology, Kerala, India. She completed her graduate studies in Polymer Science from School of Chemical Sciences, Mahatma Gandhi University, Kerala, India. Chandra P. Sharma iChandra P. Sharma is Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, and Hon. Emeritus Professor, College of Biomedical Engineering & Applied Sciences, Purbanchal University, Nepal. He was formerly Senior Scientist, G and Head, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum and has been Head, Biosurface Technology Division, SCTIMST, Trivandrum. He has also been Associate Head, Biomedical Technology Wing, and Associate Dean, SCTIMST Trivandrum. He has been recognized with various awards and honors such as MRSI medal (1994) and MRSI-ICSC Superconductivity & Materials Science Annual Prize Award 2009 - Materials Research Society of India, Distinguished Scientist award - Society for Biomaterials and Artificial Organs, India (SBAOI) and shares Whitaker and National Science Foundation Award - International Society for Artificial Organs (ISAO) USA.

List of figures and tables

Figures
Tables


About the authors
1: Diabetes mellitus - an overview

Abstract
1.1 Diabetes mellitus - an introduction
1.2 Glucose homeostasis
1.3 Types of diabetes
1.4 Symptoms of diabetes
1.5 Complications of diabetes
1.6 Diagnosis of diabetes mellitus
1.7 Therapy for diabetes
1.8 Non-insulin treatment options of type 1 diabetes
1.9 Treatment options of type 2 diabetes
1.10 Conclusion


2: Routes of administration of insulin

Abstract
2.1 Current approach for the delivery of insulin
2.2 Routes of administration of insulin
2.3 Conclusion


3: Oral insulin delivery - challenges and strategies

Abstract
3.1 Oral delivery of insulin
3.2 Barriers to oral delivery of insulin
3.3 Strategies and alternatives to improve oral insulin delivery
3.4 Conclusion


4: Experimental techniques involved in the development of oral insulin carriers

Abstract
4.1 Introduction
4.2 Polymeric nanoparticles
4.3 Physicochemical characterization of nanoparticles
4.4 Biological evaluation
4.5 In vitro method for assessing drug permeability
4.6 In vivo study of oral insulin
4.7 Biodistribution studies
4.8 Conclusion


5: Lipids and inorganic nanoparticles in oral insulin delivery

Abstract
5.1 Lipid-based systems for oral delivery of insulin
5.2 Liposomes
5.3 Solid lipid nanoparticles
5.4 Nanostructured lipid carriers
5.5 Niosomes
5.6 Archaeosomes
5.7 Cubic nanoparticles (cubosomes)
5.8 Aquasomes
5.9 Inorganic nanoparticles as carriers for oral insulin delivery
5.10 Conclusion


6: Polymers in oral insulin delivery

Abstract
6.1 Introduction
6.2 Characteristics of an ideal oral insulin carrier
6.3 Polymers in oral insulin delivery
6.4 Natural polymers
6.5 Synthetic polymers
6.6 Conclusion


7: Summary and future perspectives for oral insulin delivery

Abstract
7.1 Introduction
7.2 Technologies developed for clinical applications of oral insulin delivery
7.3 Conclusions and future perspectives


Index