Progress in Chemical Toxicology (eBook)

Front Cover 1
Progress in Chemical Toxicology 4
Copyright Page 5
Table of Contents 10
CONTRIBUTORS 6
PREFACE 8
CONTENTS OF OTHER VOLUMES 12
CHAPTER 1. INTERFERING COMPOUNDS AND ARTIFACTS IN THE IDENTIFICATION OF DRUGS IN AUTOPSY MATERIAL 14
I. Introduction 14
II. Origin and Occurrence of Interfering Compounds 15
III. Interfering Compounds (a) Extractable by Organic Solvents from Aqueous Acid Solution 21
IV. Interfering Substances (c) Extractable by Organic Solvents from Aqueous Solution at pH 9 39
V. Interfering Compounds (b) Extractable by Organic Solvents from Aqueous, Strongly Alkaline Solution 47
VI. Incidence of Interfering Endogenous Compounds 62
References 67
CHAPTER 2. PAPER AND THIN LAYER CHROMATOGRAPHIC TECHNIQUES FOR SEPARATION AND IDENTIFICATION OF BARBITURATES AND RELATED HYPNOTICS 72
I. Introduction 72
II. Facing the Problem 73
III. Isolation and Preliminary Tests 89
IV. Paper Chromatography 110
V. Thin Layer Chromatography 125
References 150
CHAPTER 3. FORENSIC CHEMICAL DETECTION OF DIGITALIS GLYCOSIDES 156
I. Introduction 156
II. Isolation and Identification Techniques for Digitalis Glycosides 157
III. Detection and Determination of Digitalis Glycosides 159
References 165
CHAPTER 4. APPLICATIONS OF ATOMIC ABSORPTION SPECTROMETRY TO TRACE METAL ANALYSES OF TOXICOLOGICAL MATERIALS 168
I. Introduction 168
II. Instrumentation for Atomic Absorption 169
III. General Atomic Absorption Procedures 172
IV. Specific Applications to Toxicological Analyses 173
References 190
CHAPTER 5. TOXICOLOGY OF INSECTICIDES, RODENTICIDES, HERBICIDES, AND PHYTOPHARMACEUTICAL COMPOUNDS 192
I. Introduction 192
II. Insecticides and Insect Repellents 193
III. Rodenticides 247
IV. Herbicides 255
V. Phytopharmaceutical Compounds 264
References 267
CHAPTER 6. COMBINED ACTION OF DRUGS WITH TOXICOLOGICAL IMPLICATIONS—PART II 270
I. Introduction 270
II. Increased Duration of Combined Drug Action 271
References 402
AUTHOR INDEX 410
SUBJECT INDEX 426