Radiolabeled Monoclonal Antibodies for Imaging and Therapy

Immunochemistry of Hybridomas.- Characterization and Selection Criteria of Monoclonal Antibodies for Tumor Imaging Studies.- Tumor Markers and Their Relevance in the Design of Radioimmunoimaging Experiments.- Selection of Monoclonal Antibodies with Optimal Biological Functions for Clinical Application.- Selection and Utilization of Monoclonal Antibody Defined Melanoma Associated Antigens for Immunoscintigraphy in Patients with Melanoma.- Development and Characterization of Human Monoclonal Antibodies and Their Application in the Radioimmunodetection of Colon Carcinoma.- Progress in Diagnostic Immunoscintigraphy and First Approach to Radioimmunotherapy of Colon Carcinoma.- The Design of a Radiolabeled Monoclonal Antibody for Radioimmunodiagnosis and Radioimmunotherapy.- Immunohistochemistry and Correlation with Plasma Levels of CA 19-9 and CEA in Gastrointestinal Tumors.- Optimization of Mouse IgG Fragmentation Technique in the Selection of Monoclonal Antibodies for Myocardial Infarct Imaging.- Sensitivity and Efficacy Indices for Oncologic Data Reporting.- Production and Use of Prospective Radionuclides for Radioimmunotherapy.- Criteria for the Selection of Nuclides for Radioimmunotherapy.- Experience with Iodine-123 Labeled Antibodies.- Radiohalogenation of Antibodies: Chemical Aspects.- Radiohalogenation of Monoclonal Antibodies: Experiences with Radioiodination of Monoclonal Antibodies for Radioimmunotherapy.- Use of Bifunctional Chelating Agents for Radiolabeling Antibodies.- Monoclonal Antibody Labeling with Indium-111 and Gadolinium via DTPA Chelation on Selective and Nonselective Sites of the Antibody.- Important Chemical Variables for Labeling Antibodies with Indium-111 and Technetium-99m.- Potential Labeling of Monoclonal Antibodies with Positron Emitters.- Quantitative Pharmacokinetics of Radiolabeled Monoclonal Antibodies for Imaging and Therapy in Patients.- Kinetic Analysis with Probability Mapping in Radioimmunoscintigraphy.- Biokinetic Studies and Scintigraphic Imaging of Human Carcinoma Xenografts with Radiolabeled Monoclonal Antibodies.- Use of an Animal Model System for Evaluating Labeled Monoclonal Antibodies.- Antibody-Hapten Complexes for Imaging.- Antibody — Carboxypeptidase G2 Conjugates as Potential Tumor Imaging Agents.- In Vivo Kinetics of Iodine-131-Monoclonal Antibodies [anti-CEA and 19-9, F(ab?)2] in Humans.- The National Institutes of Health Experience with Radiolabeled Monoclonal Antibodies: Lymphoma, Melanoma, and Colon Cancer.- Adjuvant Radioimmunotherapy for Micrometastases: A Strategy for Cancer Cure.- Quantitative Imaging and Internal Radiation Dosimetry in the Therapeutic Use of Labeled Monoclonal Antibodies.- The Distribution of Halogenated (At-211 or I-125) Tumor Specific Antibody in Tumor Bearing and Control Mice.- State-of-the-Art and Performance Testing of Instrumentation for the Scintigraphic Detection of Tumors with Labeled Monoclonal Antibodies.- Theoretical Limitations of Tumor Imaging.- Image Subtraction Techniques in Immunoscintigraphy.- Digital Superimposition of Single Photon Emission Computerized Tomography (SPECT) and CT Images for Immunoscintigraphy.- Radioimmunoscintigraphy — SPECT With I-131-MAbs; Comparison with TCT in the Follow-up of Colorectal Cancer.- Comparative Prospective Detection of Recurrences of Carcinomas with SPECT Imaging Using Radiolabeled Monoclonal Antibodies, Ultrasonography and Computed Tomography.- NMR Enhancement with Gd Labeled Antibodies.- Preclinical and Clinical Studies with Indium-111 anti-CEA Antibodies and Fragments.- Clinical Experience inCancer Diagnosis with Radiolabeled Monoclonal Antibodies in 200 Patients and Initial Attempts at Radioimmunotherapy.- Tumor Radioimmunodetection by anti-Melanoma and anti-CEA Monoclonal Antibodies: Pilot and Prospective Studies.- Tumor Immunoscintigraphy: Multicenter Clinical Trials of the Italian National Research Council (CNR).- Interstitial and Intravenous Application of Monoclonal Antibody F(ab?)2 Fragments in the Detection of Lymph Node Metastases: Benefits and Problems with Both Routes of Administration.- Radioimaging of Melanoma and CEA Secreting Tumors by Monoclonal Antibodies Performed by Different Routes of Administration.- A Monoclonal Antibody (Po66-2) Reactive with Human Lung Squamous Cell Carcinoma — Cell Reactivity In Vitro and Preliminary Scintigraphic Trials.- Monoclonal Antibodies Against Human Osteosarcoma: Preliminary Studies.- Radioimmunotherapy of Cancer: Historical Perspectives and Prospects for the Future.- Recent Perspectives on the Use of Radiolabeled Monoclonal Antibodies for Immunotherapy.- Intraperitoneal Therapy of Ovarian Cancer with Radiolabeled Monoclonal Antibodies.- Radioactive Monoclonal Antibodies Against Cell Surface Antigens for Labeling Leukocyte Subpopulations.- Monoclonal Antibody Against Human Fibrin for Imaging Thrombi.- Radiolabeled Antiplatelet Monoclonal Antibodies for the Scintigraphic Localization of In-vivo Thrombi and Vascular Lesions.- Potential of Radiolabeled Antiplatelet Antibodies in the Detection of Vascular Thrombi.- List of Participants.- Author Index.