Celiac Disease

S. Devi Rampertab, MD, FACG UMDNJ-Robert Wood Johnson Medical School, Department of Medicine, New Brunswick, NJ, USA Gerard E. Mullin, MD Johns Hopkins University School of Medicine, Department of Gastroenterology, Baltimore, MD, USA

Introduction.- Definition of Celiac Disease and Gluten Sensitivity.- Epidemiology of Celiac Disease.- The Pathophysiology of Celiac Disease.- Immunogenetics of Celiac Disease.- Using Animal Models of Celiac Disease to  Understand the Role of MHC II.- Role of Gut Microbes in Celiac Disease Risk and Pathogenesis.- Presentation of Celiac Disease in Children and Adults.- Diagnosis of Celiac Disease.- Nutrition in Celiac Disease.- Dietary Supplements in Celiac Disease.- Monitoring and Follow-up of Patients with Celiac Disease.- Special Considerations in Children and Young Adults with Celiac Disease.- Novel and Experimental Therapies on the Horizon.- Morbidity and Mortality Associated with Celiac Disease.- Refractory Celiac Disease.- Celiac Disease: Dispelling Misconceptions and Myths.- Summary of Recommendations from the American College of Gastroenterology Celiac Disease Guidelines.- Resources for Celiac Disease Practitioners and Patients.- Taxonomic Relationships of the Major Cereal Grains.- Some Potential Sources of Hidden Gluten.- Key Elements in the Management of Celiac Disease.- Celiac Iceberg.- An Approach to Gluten Challenge for the Diagnosis or Exclusion of Celiac Disease.- An Approach to the Monitoring of Celiac Disease.- An Approach to the Diagnosis of Celiac Disease.- An Approach to the Patient with Non-Responsive Celiac Disease.- Dietary Reference Intakes (DRIs): Recommended Dietary Allowance and Adequate Intakes, Vitamins and Elements.- Dietary Reference Intakes (DRIs): Tolerable Upper Intake Levels, Vitamins and Elements.