Neural Crest Cells

Paul Trainor, PhD is an Investigator at the Stowers Institute for Medical Research in Kansas City, MO USA with over 20 years of experience working in the fields of developmental biology, neurobiology and craniofacial morphogenesis. He received his PhD from the University of Sydney, Australia under the tutelage of Dr Patrick Tam before undertaking post-doctoral training with Dr Robb Krumlauf at the National Institute for Medical Research in London, England. The current emphasis of Dr Trainor’s research centres on the role of neural crest cells in craniofacial evolution, development and disease. He seeks to understand the mechanisms that regulate neural crest cell patterning and apply this basic knowledge to decipher the etiology and pathogenesis of birth defects and potentially develop therapeutic avenues for their prevention. His laboratory studies neurocristopathies (disorders of neural crest cell development) such as Treacher Collins syndrome, Holoprosencephaly and Syngnathia as well as other neurocristopathy disorders such as Hirschsprung disease. Dr Trainor is currently vice-present of the Society for Craniofacial Genetics and Development.

Part 1: Neural Crest Cell Evolution and Development

Ch 1. The Evolution of Neural Crest Cells;Ch 2. Neural Crest Cell Induction and Specification – Signals and Switches; Ch 3. Neural Crest Cell Delamination – Cell Adhesion and Polarity; Ch 4. Neural Crest Cell Migration – Guidance and Pathways; Ch 5. Epigenetic Regulation of Neural Crest Cells; Ch 6. Neural Crest Stem and Progenitor Cells; Ch 7. Neural Crest Cells and Tissue Interactions – Species specificity, growth, shape, patterning and programming

Part II: Neural Crest Cell Differentiation and Disease

Ch 8. Neural Crest Cells in Cranioskeletal Development; Ch 9. Neural Crest Cells and Placode Interactions in Cranial PNS Development; Ch 10. Neural Crest Cells in Ear Development; Ch 11. Neural Crest Cells in Eye Development; Ch 12. Neural Crest Cells in Heart Development; Ch 13. Neural Crest Cells in Enteric Nervous System Formation; Ch 14. Neural Cells and Trunk PNS Formation; Ch 15. Neural Crest Cells in Melanocyte Development and Pigmentation; Ch 16. Neural Crest Cells in Vasculogenesis; Ch 17. Neural Crest Cells as a Model for Metastasis and Cancer

Part III: Tissue Engineering and Repair

Ch 18. Neurocristopathies; Ch 19. Neural Crest Cells in Human Embryos – implications for iPS; Ch 20. Neural Crest Stem Cells in Tissue Regeneration and Repair; Ch 21. Neural crest cells in tooth development and repair; Ch 22. Disease Specific iPS Neural Crest Cells