Therapeutic Vaccination Strategies

This book offers an overview of current experimental therapies for tumours and autoimmune disease. The approaches described include use of tumor antigens and application of costimulatory molecules or transformed T-cell clones. Other topics are the obligatory immunomonitoring and the choice of suitable vectors for DNA vaccination. Early clinical experience is reported, and the necessary legal and regulatory provisions are discussed TOC:Vaccination Therapy for Malignant Disease: The Clinical Perspective; Tumour Antigens; Costimulatory Molecules in Vaccine Design; Application of T Cell Immunotherapy for Human Viral and Malignant Diseases; Immune Monitoring in Cancer Immunotherapy; Retroviral Vectors for Cancer Gene Therapy; CpG-oligonucleotides as Immune Adjuvants; DNA Vaccination Against Cancer Antigens; Skin Cancer - Prospects for Novel Therapeutic Approaches; The Hybrid Cell Vaccination Approach to Cancer Immunotherapy; T Cell Receptor Peptides for the Vaccination Therapy of Multiple Sclerosis; Regulatory Aspects of Cancer Gene Therapy and DNA Vaccination.