Therapeutic Advances in Thrombosis (eBook)

David Moliterno, M.D, co-director of the Gill Heart Institute, professor of Internal Medicine and division chief of Cardiovascular Medicine at the University of Lexington, Kentucky. He is also inaugurated as the American College of Cardiology Governor of the Kentucky chapter for the years 2007-2010. He has 189 articles published as listed on PubMed and is the author of the following books: Therapeutic Strategies in Thrombosis 1E; 900 Questions: An Interventional Cardiology Board Review. Raffaele De Caterina, MD, Institute of Cardiology, "G. d'Annunzio" University, Chieti, Italy. He has 261 articles published as listed on PubMed and is the author of the following books: Therapeutic Strategies in Thrombosis 1E; Endothelial Dysfunctions and Vascular Disease. Steen Dalby Kristensen, Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark. He has 91 articles published as listed on PubMed and is the author of the following books: Therapeutic Strategies in Thrombosis 1E.

Contributors, vii

Foreword, x

Preface, xi

1 Arterial thrombosis: a brief overview, 1
Lina Badimon and Valentin Fuster

2 Aspirin, 12
Carlo Patrono

3 Platelet ADP P2Y12 inhibitors: thienopyridines, 26
Joseph D. Foley III and David J. Moliterno

4 Platelet ADP P2Y12 inhibitors: nonthienopyridines, 47
Joseph D. Foley III and David J. Moliterno

5 Cilostazol and dipyridamole: more than weak inhibition ofplatelets, 62
Wolfgang G. Eisert

6 Interrelationship of thrombin and platelets: the proteaseactivated receptor-1, 71
Matthew E. Wiisanen and David J. Moliterno

7 Glycoprotein IIb/IIIa inhibitors, 87
Marco Valgimigli and Elisa Cangiano

8 Unfractionated heparin and low molecular weight heparin inischemic heart disease, 111
Zafar Iqbal, Omar Hasan, and Marc Cohen

9 Pentasaccharide derivatives, 128
Antonio Gutierrez, Pierluigi Tricoci, and John H.P.Alexander

10 Intravenous direct thrombin inhibitors, 150
Femi Philip and A. Michael Lincoff

11 Vitamin K antagonists, 166
Freek W.A. Verheugt

12 Oral direct thrombin inhibitors and oral factor Xainhibitors, 180
Steen Husted and Lars Wallentin

13 Thrombolytic therapy and concomitant antithrombotictherapies, 189
Peter R. Sinnaeve and Frans J. Van de Werf

14 Antithrombotic therapy in ST-segment elevation myocardialinfarction, 205
Kurt Huber, Raffaele De Caterina, and Steen DalbyKristensen

15 Antithrombotic therapy in non-ST-segment elevationacute coronary syndromes, 213
Georgios J. Vlachojannis, Vijayalakshmi Kunadian, Joseph M.Sweeny, and Roxana Mehran

16 Antithrombotic strategies in patients undergoing electivepercutaneous coronary intervention, 236
Sunil V. Rao and E. Magnus Ohman

17 Antithrombotic management in patients with prosthetic valves,246
Eric G. Butchart and Raffaele De Caterina

18 Stroke: thrombolysis and antithrombotic therapy, 272
L. Creed Pettigrew and Michael R. Dobbs

19 Atrial fibrillation: current and forthcoming antithrombotictherapies, 285
Raffaele De Caterina and Giulia Renda

20 Venous thromboembolism: pathophysiology, diagnosis, andprophylaxis, 306
Marco P. Donadini, Walter Ageno, and Alexander G. Turpie

21 Antithrombotic therapy in venous thrombosis and pulmonaryembolism, 317
Marcello Di Nisio and Harry R. Büller

22 Prevention and treatment of venous and arterial thrombosis inpatients with specific conditions: diabetes, hypercoagulablestates, pregnancy, and renal insufficiency, 327
Meyer Michel Samama, Jacqueline Conard, and GrigorisGerotziafas

23 Genetics of the response to antithrombotic drugs and the needfor monitoring, 357
Jean-Philippe Collet, Gilles Montalescot, andJean-Sébastien Hulot

Index, 378