Novel Therapeutic Targets for Antiarrhythmic Drugs (eBook)

GEORGE EDWARD BILLMAN is a professor at The Ohio State University. He is currently an Associate Editor of Pharmacology and Therapeutics, an Editor of Experimental Physiology, and on the editorial boards of Journal of Cardiovascular Pharmacology and Journal of Applied Physiology. Dr. Billman has authored over 125 journal articles and has been an invited speaker at twenty national and international scientific meetings. He wrote the chapter "Cardiac Sarcolemmal ATP-Sensitive Potassium Channel Antagonists" in Drug Discovery Handbook (Wiley).

Acknowledgments.

Contributors.

1. Introduction (George E. Billman).

2. Myocardial K¯+ Channels: Primary Determinants of Action Potential Repolarization (Noriko Niwa and Jeanne Nerbonne).

3. The "Funny" Pacemaker Current (Andrea Barbuti, Annalisa Bucchi, Mirko Baruscotti, and Dario DiFrancesco).

4. Arrhythmia Mechanisms in Ischemia and Infarction (Ruben Coronel, Wen Dun, Penelope A. Boyden, and Jacques M.T. de Bakker).

5. Antiarrhythmic Drug Classification (Cynthia A. Carnes).

6. Repolarization Reserve and Proarrhythmic Risk (András Varró).

7. Safety Challenges in the Development of Novel Antiarrhythmic Drugs (Gary Gintant and Zhi Su).

8. Safety Pharmacology and Regulatory Issues in the Development of Antiarrhythmic Medications (Armando Lagrutta and Joseph J. Salata).

9. Ion Channel Remodeling and Arrhythmias (Takeshi Aiba and Gordon F. Tomaselli).

10. Redox Modification of Ryanodine Receptors in Cardiac Arrhythmia and Failure: A Potential Therapeutic Target (Andriy E. Belevych, Dmitry Terentyev, and Sandor Györke).

11. Targeting Na ¯+ /Ca¯2+ Exchange as an Antiarrhythmic Strategy (Gudrun Antoons, Rik Willems, and Karin R. Sipido).

12. Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII)-Modulation of Ion Currents and Potential Role for Arrhythmias (Dr. Lars S. Maier).

13. Selective Targeting of Ventricular Potassium Channels for Arrhythmia Suppression: Feasible or Risible? (Hugh Clements-Jewery and Michael Curtis).

14. Cardiac Sarcolemmal ATP-sensitive Potassium Channel Antagonists: A Class of Drugs that May Selectively Target the Ischemic Myocardium (George E. Billman).

15. Mitochondrial Origin of Ischemia-Reperfusion Arrhythmias (Brian O'Rourke, PHD).

16. Cardiac Gap Junctions: A New Target for New Antiarrhythmic Drugs: Gap Junction Modulators (Anja Hagen and Stefan Dhein).

17. Novel Pharmacological Targets for the Management of Atrial Fibrillation (Alexander Burashnikov and Charles Antzelevitch).

18. Ikur, Ultra-rapid Delayed Rectifier Potassium Current: A Therapeutic Target for Atrial Arrhythmias (Arun Sridhar and Cynthia A. Carnes).

19. Non-Pharmacologic Manipulation of the Autonomic Nervous System in Human for the Prevention of Life-Threatening Arrhythmias (Peter J. Schwartz).

20. Effects of Endurance Exercise Training on Cardiac Autonomic Regulation and Susceptibility to Sudden Cardiac Death: A Nonpharmacological Approach for the Prevention of Ventricular Fibrillation (George E. Billman).

21. Dietary Omega-3 Fatty Acids as a Nonpharmacological Antiarrhythmic Intervention (Barry London and J. Michael Frangiskakis).

General Index.

Index of Drug and Chemical Names.

"In Summary, the book is a good, comprehensive reference for
knowledge on arrhythmia and its treatment, and is considered as
worthwhile addition to the literature on cardiac arrhythmia and
antiarrhythmic drugs." (ChemMedChem, July 2010)

"George Billman has assembled a terrific book that will serve the
needs of students, clinical and research faculty with interests in
cardiac arrhythmias, antiarrhythmic drugs and ion channel biology."

--Mark E. Anderson, M.D., Ph.D. Professor, Departments
of Internal Medicine and Molecular Physiology & Biophysics
Head, Department of Internal Medicine François M. Abboud Chair
in Internal Medicine

"The information presented in each individual chapter is of
superb quality, still providing the information in such a detailed
way that even the knowledge of the specialists in the field will be
challenged. The topics covered, however, are so broad that the
mentioned specialist will also find chapters of great interest to
his common knowledge in other fields. In this era of PubMed, the
younger scientists will be pleased to find detailed referencing,
including papers going back many decades, revealing information
well in the last century. Therefore, I recommend this book to
individuals still interested in the mechanism behind arrhythmias
and the way that this knowledge can be applied to new therapeutic
strategies."

--Marc Vos, PhD, University Medical Center Utrecht