Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors -

Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors

Terry P. Kenakin (Herausgeber)

Buch | Hardcover
488 Seiten
2013
Academic Press Inc (Verlag)
978-0-12-394587-7 (ISBN)
147,15 inkl. MwSt
Reflects on developments and research surrounding G protein-coupled receptors. This title includes chapters that cover a large breadth of research, including GPCR role in stem cell function and pharmacology.
In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology.

Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.

Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors
Michael T. Klein, Paige N. Vinson and Colleen M. Niswender

Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders
Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender

Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery
Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis

G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design
Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri

GPCRs in Stem Cell Function
Van A. Doze and Dianne M. Perez

Application of Receptor Theory to Allosteric Modulation of Receptors
David A. Hall

What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors
Frederick J. Ehlert

Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors
Jesús Giraldo

Chemokine Receptor Oligomerization and Allostery
Bryan Stephens and Tracy M. Handel

Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac

Erscheint lt. Verlag 18.4.2013
Reihe/Serie Progress in Molecular Biology and Translational Science
Verlagsort San Diego
Sprache englisch
Maße 152 x 229 mm
Gewicht 710 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete
Studium 1. Studienabschnitt (Vorklinik) Physiologie
ISBN-10 0-12-394587-9 / 0123945879
ISBN-13 978-0-12-394587-7 / 9780123945877
Zustand Neuware
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