Myocardial Ischemia and Arrhythmia

Under the auspices of the Society of Cooperation in Medicine and Science (SCMS), Freiburg, Germany

M. Zehender, T. Meinertz, H. Just (Herausgeber)

Buch | Softcover

XVI, 301 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1994
Steinkopff (Verlag)
978-3-642-72507-4 (ISBN)

Artikel merken

During recent years, it has become evident that ventricular arrhythmias may arise from myocardial ischemia and that they may be harbingers of sudden cardiac death. On the other hand, ventricular arrhythmias may occur without any prognostic significance and sudden cardiac arrhythmic death may strike without any warning arrhythmia. The role of ischemia in the genesis of ventricular arrhythmias and of sudden cardiac death has been observed beyond doubt. However, the mechanism by which ischemia leads to the appearance of ventricular arrhythmias and/or sudden cardiac death has remained rather poorly understood, inspite of rather remarkable research efforts on the one hand, and the magnitude of the problem on the other hand. We have therefore set out to assemble scientists from around the world in order to define the current state of our knowledge on myocardial ischemia and arrhythmia. Well in line with the tradition of the Gargellen Conferences, we assembled clinicians and basic scientists for the 7th Gargellen Conference. This book presents the proceed ings of the Symposium in the attempt to define the current status of our understand ing of this significant problem. The Symposium was organized by the Society for Cooperation in Medicine and Science (SCMS) and was generously sponsored by Astra Chemicals, Wedel; Bayer AG, Leverkusen; Boehringer-Mannheim; CPI-Lilly, Giessen; Janssen GmbH, Neuss; Minden Pharma, Minden; Rahm Pharma, Weiter stadt; Schering AG, Berlin, and Siemens AG, Erlangen.

Metabolic aspects and channel kinetics in cellular hypoxia.- Calcium homeostasis, myocardial ischemia and arrhythmogenic impact.- Selected metabolic alterations in the ischemic heart and their contributions to arrhythmogenesis.- Arrhythmogenic effects of selective inhibition of cyclic nucleotide phosphodiesterase isoenzymes in pig myocardium.- Ischemia and early extracellular K+ accumulation in cardiac cells.- Characteristics of transport processes involved in ischemia and reperfusion.- Ionic and metabolic progenitors of reperfusion arrhythmias.- Electrophysiologic properties of cellular hypoxia and myocardial ischemia.- Anisotropy and anisotropic reentry in myocardial infarction.- Effects of the sympathetic nervous system on conduction and refractoriness in normal and ischemic myocardium.- Sympatho-adrenergic activation of the ischemic myocardium and its arrhythmogenic impact.- Factors determining the arrhythmogenic potency of myocardial ischemia and time-course of ischemia related arrhythmias.- Pathophysiology of acute ischemia: Potential targets for Antiarrhythmic drugs.- Acute and chronic myocardial ischemia in the arrhythmogenesis and aggravation of ventricular arrhythmias.- Risk stratification and prediction of sudden death following myocardial infarction.- Ventricular tachyarrhythmias, myocardial ischemia and sudden cardiac death in patients with hypertensive heart disease.- Vascular mechanisms leading to myocardial ischemia and their relation to hypertension, left ventricular hypertrophy and arrhythmias.- Clinical evidence for the fatal interaction of ventricular tachyarrhythmias, myocardial ischemia and sudden cardiac death.- Autonomic nervous system, myocardial ischemia, and malignant ventricular arrhythmias: Experimental findings.- Assessment of autonomic tonus and reflexes in patients after myocardial infarction.- Clinical aspects in the treatment of ischemia-related ventricular arrhythmias.- Coronary artery bypass graft surgery for the prevention of sudden cardiac death.- Myocardial ischemia, ventricular arrhythmias and implantable cardioverter-defibrillators: Importance of stored electrograms.- Therapeutic consequences of newer studies addressing the problem of myocardial ischemia and ventricular arrhythmias.

Erscheint lt. Verlag	10.12.2011
Zusatzinfo	XVI, 301 p. 14 illus.
Verlagsort	Heidelberg
Sprache	englisch
Maße	170 x 244 mm
Gewicht	554 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
Schlagworte	Arrhythmia • Artery • Bypass • coronary heart disease • Drugs • heart • Heart disease • Hypertension • myocardial arrhythmia • Myocardial Infarction • Myocardial ischemia • Physiology • sudden cardiac death
ISBN-10	3-642-72507-4 / 3642725074
ISBN-13	978-3-642-72507-4 / 9783642725074
Zustand	Neuware