Recent Advances in Cell Biology of Acute Leukemia

Prof. Dr. Wolf-Dieter Ludwig, Arzneimittelkommission der deutschen Ärzteschaft, Berlin.

I. Hematopoietic Differentiation.- Differentiation of Physiological and Malignant Cells of the B-Cell System.- Expression of B-Cell-Associated Antigens During B-Cell Ontogeny.- Normal and Aberrant T-Cell Receptor Protein Expression in T-Cell Acute Lymphoblastic Leukemia.- Flow Cytometric Analysis of Intracellular Myeloperoxidase and Lactoferrin in Leukemia Diagnosis.- II. Phenotypic Heterogeneity in Acute Leukemias: Immunological Characterization and Clinical Relevance.- Immunological, Ultrastructural and Molecular Features of Unclassifiable Acute Leukaemia.- Incidence and Clinical Relevance of Myeloid Antigen-Positive Acute Lymphoblastic Leukemia.- Myeloid-Associated Antigen Expression in Childhood Acute Lymphoblastic Leukemia.- Contribution of Electron Microscopy to the Classification of Minimally Differentiated Acute Leukemias in Children.- III. Biological and Clinical Significance of Cytogenetic Abnormalities in Acute Leukemias.- Molecular Cytogenetic Applications in Leukemias.- Cytogenetic Abnormalities Associated with Childhood Acute Myeloblastic Leukemia.- DNA Aneuploidy in Childhood Acute Lymphoblastic Leukemia: Relation to Clinical Determinants and Prognosis within Four Consecutive BFM Trials.- Clinical Significance of Cytogenetic Studies in Childhood Acute Lymphoblastic Leukemia: Experience of the BFM Trials.- Chromosomal Abnormalities in Adult Acute Lymphoblastic Leukemia: Results of the German ALL/AUL Study Group.- IV. Minimal Residual Disease in Acute Leukemias: Detection and Immunotherapeutic Strategies.- Molecular Genetic Techniques for Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia: Possibilities and Limitations.- Immunophenotypic and Immunogenotypic Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia.- Detectionof Aberrant Antigen Expression in Acute Myeloid Leukemia by Multiparameter Flow Cytometry.- Detection of Residual Leukemic Cells in Adult Acute Lymphoblastic Leukemia by Analysis of Gene Rearrangements and Correlation with Early Relapses.- Interleukin-2-Based Immunotherapy in the Management of Minimal Residual Disease in Acute Leukemia Patients.- Preclinical Studies of T-Cell-Mediated Immune Responses Against Autologous Tumor Cells in Patients with Acute Leukemia.- Susceptibility of Human Leukemia Cells to Allogeneic and Autologous Lymphokine-Activated Killer Cells and Its Augmentation by Exposure of Leukemia Target Cells to Cytotoxic Drugs In Vitro and In Vivo.- V. Immunophenotypic and Molecular Genetic Characterization of Acute Lymphoblastic Leukemia: Biological and Clinical Implications.- Regulation of Protooncogenes and Cytokine Genes in Acute Lymphoblastic Leukemia.- Cellular Drug Sensitivity of Immunophenotypic Subgroups of Childhood Acute Lymphoblastic Leukemia.- Use of Clinical and Laboratory Features to Define Prognostic Subgroups in B-Precursor Acute Lymphoblastic Leukemia: Experience of the Pediatric Oncology Group.- Incidence and Prognostic Significance of Immunophenotypic Subgroups in Childhood Acute Lymphoblastic Leukemia: Experience of the BFM Study 86.- Incidence, Clinical and Laboratory Features, and Prognostic Significance of Immunophenotypic Subgroups in Acute Lymphoblastic Leukemia: The GEIL Experience.- Incidence and Prognostic Significance of Immunophenotypic Subgroups in Childhood Acute Lymphoblastic Leukemia: The Experience of the AIEOP Cooperative Study.- Mutations in the Regulatory Domains of bcr/abl-Positive Leukemias Detected by Solid-Phase Automated DNA Sequencing.- VI. Leukemic Cell Characterization in Acute Myeloid Leukemia: Biological andClinical Implications.- Clonal Analysis of n-ras Gene Activation in Acute Myeloid Leukemia.- Human Stem Cell Factor is a Growth Factor for Myeloid Leukemia Cells.- Morphologic Basis for the MIC Classification in Acute Myeloid Leukemia.- Molecular Genetics of the t(15;17) Translocation in Acute Promyelocytic Leukemia.- Immunophenotype of Hematologic Neoplasms with a Translocation t(8;21).- Diagnostic and Prognostic Importance of Immunophenotyping in Adults with Acute Myeloid Leukemia.- Immunophenotype of Acute Myeloid Leukemia: Correlation with Morphological Characteristics and Therapy Response.- Multiparameter Analysis of Blast Cells in Patients with Acute Leukemia Following a Primary Myelodysplastic Syndrome.