Erythropoietin

Wolfgang Jelkmann, Andreas J. Gross (Herausgeber)

Buch | Softcover

XIII, 180 Seiten

2012 | 1. Softcover reprint of the original 1st ed. 1989
Springer Berlin (Verlag)
978-3-642-83747-0 (ISBN)

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Recent developments in recombinant DNA technology have led to the large-scale production of human erythropoietin and to the demonstration that it is effective in the treatment of renal and possibly some other anaemias. This has lent a new impetus to studies of the pathophysiology and pharmacology of the hormone which is reflected in this report of the proceedings of a meeting held in Liibeck in June 1988. In 15 papers, all from European centres, the broad topics covered are erythropoietin's physiology and chemistry, the patho physiology of erythropoiesis and the use of erythropoietin in the treatment of anaemia. Several of the papers include up-to-date reviews of the literature. The field is now expanding rapidly, and this volume, though not comprehensive, usefully points up many areas of recent understanding as well as others of continuing un certainty. Overall, it contains material likely to be of interest to biochemists and experimental haematologists as well as to phar macologists, clinical haematologists and nephrologists.

List of Contents.- Introduction: Advances in Erythropoietin Research.- Chemistry and Physiology.- Chemistry and Assays of Erythropoietin.- Erythropoietin Production Under Steady-State Conditions: Detection and Localization Using In Situ Hybridization.- Erythropoietin Synthesis in the Anemic Mouse Kidney as Observed by Morphological Techniques.- Tissue Hypoxia and the Production of Erythropoietin.- Early Anemia in Mammals.- Pathophysiology of Erythropoiesis.- Physiological Studies of Erythropoietin in Plasma.- Erythropoietin Production in Malignancy.- Pathophysiology of Erythropoiesis in Renal Diseases.- Renal Artery Stenosis and Renal Polyglobulia.- Erythrocytosis in Renal Graft Recipients.- Erythropoietin in the Treatment of Anemia.- Recombinant Human Erythropoietin.- Erythropoietin, Blood Viscosity, and Hypertension: Implications for Patients with End-Stage Renal Disease.- Recombinant Human Erythropoietin and CIS-Retinoic Acid Therapy of Anemia in Hemodialysis and Peritoneal Dialysis Patients.- Clinical Effects of Partial Correction of Anemia Using Recombinant Human Erythropoietin on Working Capacity in Dialysis Patients.- In Vitro and In Vivo Regulation of Erythropoiesis.

Erscheint lt. Verlag	1.3.2012
Vorwort	Mary Cotes
Zusatzinfo	XIII, 180 p. 13 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	311 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Nephrologie
Schlagworte	anemia • Blood • Cells • Chemistry • clinical trial • pathophysiology • Physiology • Research
ISBN-10	3-642-83747-6 / 3642837476
ISBN-13	978-3-642-83747-0 / 9783642837470
Zustand	Neuware