HLA Class II Antigens

Molecular Biology.- Genes and Antigens of the HLA-D Region.- Physiologic Regulation of Class II Major Histocompatibility Complex Gene Expression.- Epitopes Are the Functional Units of HLA Class II Molecules and Form the Molecular Basis for Disease Susceptibility.- Biochemistry.- Structure of Human Class II Antigens Expressed by a Homozygous Lymphoblastoid B Cell Line.- The Complexity of HLA-DQ Molecules.- HLA-DP: Current Status.- Genes Encoding Mouse Ia.- Structural and Functional Studies of Mouse Class II Genes.- Cross-reaction Between Various Species.- Cross-reactions of Class II Histocompatibility Antigens of Various Species.- Differences Between Ethnic Groups.- Human Class II Antigen in Different Ethnic Groups.- Serological Definition.- Serology of HLA Class II Antigens: Methodological Aspects.- Alloantisera Against Human Class II Antigens: Definition and Methodology.- Monoclonal Antibodies Against HLA Class II Antigens.- Preparation, Characterization and Utilization of Monoclonal Antibodies to the Gene Products of the HLA-D Region, with Special Emphasis on those to Polymorphic Determinants.- Cellular Detection.- Cellular Detection of HLA Class II-Encoded Determinants: Subtype Polymorphims of HLA-D.- Cellular Detection of Human Class II MHC Antigens by Alloreactive T Cell Clones.- Cellular Detection of Human Class II Antigens: Delineation of a Novel HLA-DP-like Suppressor Restriction System DY, the Sequential Expression of Class II Antigens, and a Pronounced Functional Flexibility of Class II Alloproliferate T Cell Clones.- Regulation and Expression.- Modulation of Class II Antigens by Interferons.- Changing Antigenic Profiles of HLA Class II Antigens on Activated T Cells and Their Biological Effects.- Tissue Distribution of Class II Transplantation Antigens: Presence on Normal Cells.- Class II MHC Antigens on Human Monocytes, Endothelial Cells, and Dendritic Cells.- Class II Antigens: T Cells.- Class II MHC Antigens and Hematopoiesis.- Class II MHC Antigens and Erythropoiesis.- Expression of Class II Antigens on Nonhematopoietic Tumor Cells.- Class II HLA Antigens in Benign and Malignant Lesions of Melanocytic Origin.- Molecular Genetics.- Molecular Polymorphism of Human Immune-Response-Genes.- Molecular Genetics as a Tool in Clinical Transplantation.- Biological Implications.- The Role of Human Class II Molecules in Activation of T4 Lymphocytes.- Class II HLA Antigens in Autoimmune and Immune-Mediated Diseases.- The Role of HLA Class II Antigens in Clinical Transplantation.- Relevance of HLA-D/-DR Matching in a National Kidney Transplant Program.- The Pig as a Model to Assess the Effect of Class II MHC Antigen Matching on Renal Allograft Survival.