Gestational Trophoblastic Disease (eBook)

ForwardPreface and DedicationChapter 1: Gestational Trophoblastic Disease: General Aspects (Pei Hui)-          Historical remarks-          Definition and classification of gestational trophoblastic disease-          Epidemiology and risk factors-          Overview of diagnosis-          Overview of clinical management-          Perspectives-          ReferencesChapter 2: Developmental Biology of the Placenta (Pei Hui)-          Introduction-          Placenta formation-          Stages of implantation-          Placental trophoblastic cells-          Genomic imprinting and placental development-          Imprinted X chromosomal inactivation and placental development-          Co-evolution of genomic imprinting and imprinted X-chromosome inactivation-          “Parental conflict of interest” theory of genomic imprinting-          ReferencesChapter 3: Genetic Basis of Gestational Trophoblastic Disease (Pei Hui)-          Introduction-          Androgenetic nature of hydatidiform moles-          Genomic imprinting and hydatidiform moles-          Genetic basis of gestational trophoblastic tumors-          Perspectives-          ReferencesChapter 4: Complete hydatidiform mole (Pei Hui)-          Introduction-          Pathogenesis-          Clinical presentation -          Pathology-          Ancillary studies -          Differential diagnosis-          Clinicopathological correlations-          ReferencesChapter 5: Partial hydatidiform mole (Natalia Buza)-          Introduction-          Genetic background-          Clinical presentation-          Pathology gross and microscopic features-          Ancillary studies-          Differential diagnosis-          Clinicopathological correlations-          ReferencesChapter 6: Placental site trophoblastic tumor (PSTT) (Pei Hui)-          Introduction-          Clinical presentation-          Pathogenesis-          Gross and histological pathology-          Ancillary studies-          Differential diagnosis-          Clinicopathological correlations-          ReferencesChapter 7: Epithelioid trophoblastic tumor (Katja Gwinn)-          Introduction-          Pathogenesis and molecular genetic aspect-          Clinical presentation-          Pathology-          Ancillary studies-          Differential diagnosis-          Clinicopathological correlations-          ReferencesChapter 8: Gestational choriocarcinoma (Pei Hui)-          Introduction-          Clinical presentation-          Pathogenesis -          Pathology-          Ancillary studies-          Differential diagnosis-          Clinicopathological correlations-          ReferencesChapter 9:Persistent gestational trophoblastic neoplasia (Pei Hui)-          Introduction-          Pathologyo   Persistent moleo   Invasive mole and metastatic moleo   Gestational trophoblastic tumors-          Prognosis-          ReferencesChapter 10:Tumor-like trophoblastic conditions (Pei Hui)-          Introduction-          Placental site nodule/plaque (PSN)o   Clinical featureso   Pathogenesiso   Pathologyo   Ancillary studieso   Differential diagnosiso   Clinicopathological correlations-          Exaggerated placental site reaction (EPS)o   Clinical featureso   Pathogenesiso   Pathologyo   Ancillary studieso   Differential diagnosiso   Clinicopathological correlations-          ReferencesChapter 11:Molecular Diagnosis of Gestational Trophoblastic Disease (Pei Hui)-          Introduction-          Genetic basis of molecular testing-          Methods of molecular diagnosis-          STR genotyping diagnosis of hydatidiform moles-          Interpretation of STR PCR data-          Target tissue selection and processing-          Diagnostic pitfalls of STR genotyping-          STR genotyping diagnosis of trophoblastic tumors-          Prospective-          Conclusions-          ReferencesChapter 12: Clinical aspects of gestational trophoblastic disease (Christine E. Richter and Peter E. Schwartz)-          Introduction -          Diagnosis-          Hydatidiform moles-          Gestational trophoblastic neoplasia-          Treatment of gestational trophoblastic neoplasia-          Treatment of PSTT and ETT-          Treatment failure GTN-          Follow-up GTN-          References Appendix:              GTD clinicopathological staging forms (AJCC 2010, Seventh Edition, Springer)