Arenaviruses (eBook)

Front Cover 1
Arenaviruses 4
Copyright Page 5
Contents 10
Preface 6
Foreword 8
Chapter 1. Introduction 14
1.1. Historical perspective 14
1.2. Classification 20
1.3. Nomenclature 20
Chapter 2. Natural History 22
2.1. Arenaviruses pathogenic for man 23
2.2. Arenaviruses non-pathogenic for man 30
Chapter 3. Laboratory diagnosis and serological properties 36
3.1. Safety considerations 36
3.2. Diagnosis of human arenavirus infection 40
3.3. Serological cross-reactivity between arenaviruses 52
3.4. Virus neutralization 55
Chapter 4. Human arenavirus infections 60
4.1. Lymphocytic choriomeningitis 61
4.2. Lassa fever 62
4.3. Argentinian haernorrhagic fever 73
4.4. Bolivian haernorrhagic fever 77
Chapter 5. Arenavirus infections of animals 84
5.1. Natural and experimental infections of rodents 84
5.2. Experimental infections of primates 111
Chapter 6. Ultrastructure of arenaviruses and infected cells 118
6.1. Appearance in thin sections 119
6.2. Virus morphology 122
6.3. Internal structures 125
Chapter 7. Physicochemical properties and chemical composition 132
7.1. Biophysical properties 133
7.2. Virus purification 137
7.3. Chemical composition 143
Chapter 8. Arenavirus replication 158
8.1. Involvement of host cell components 160
8.2. Synthesis of virus-specific polypeptides 162
8.3. RNA synthesis and genome replication 167
8.4. Replication in persistently infected cells 173
Chapter 9. Immunology of arenavirus infections 182
9.1. Interactions with cells of the host-immune system 183
9.2. Acute infection 186
9.3. Chronic persistent infection 195
Chapter 10. Treatment and prevention of human infections 202
10.1. Antiviral compounds 203
10.2. Passive immunization: the use of immunoglobulin 205
10.3. Active immunization: the development of a vaccine against Argentine haemorrhagic fever 211
10.4. Prospects for the development of a Lassa fever vaccine 218
References 222
Subject Index 260