Alzheimer's Disease: Insights Into Low Molecular Weight And Cytotoxic Aggregates From In Vitro And Computer Experiments - Molecular Basis Of Amyloid-beta Protein Aggregation And Fibril Formation

Cellular and In Vitro Aspects of Amyloid-Beta (Aβ) Aggregation: Amyloid Hypothesis: Molecular and Cellular Aspects of Toxicity (Rakez Kayed and Cristian A Lasagna-Reeves); Models of Wild-Type and Disease-Causing Mutant β-Amyloid Fibrils. Insights from Solid-State Nuclear Magnetic Resonance Spectroscopy (Stephen C Meredith); Biophysical Characterization of Aβ Assembly (Eric Y Hayden and David B Teplow); Coordination of Metal Ions to β-Amyloid Peptide: Impact on Alzheimer's Disease (Peter Faller, Giovanni La Penna, Christelle Hureau and Sara Furlan); Amyloidogenesis, Neurogenesis, Learning, and Memory in Alzheimer's Disease: Lessons from Transgenic Mouse Models (Laure Verret and Claire Rampon); Inhibitor Design Against Cytotoxic β-Amyloid Species (Andrew J Doig); Bioinformatics and Computer Simulations of Aβ Aggregation Under Various Environmental Conditions: Kinetics of Amyloid Growth (Jessica Nasica-Labouze and Normand Mousseau); Probing the Stability of Fibril and Tubular Species Using All-Atom Molecular Dynamics Simulations in Solution: Insight into Polymorphism (Yifat Miller, Buyong Ma and Ruth Nussinov); Mechanisms of Growth of β-Amyloid Fibrils and Binding of Non-Steroidal Anti-Inflammatory Drug Ligands (Takako Takeda and Dmitri Klimov); Exploring the Structures of β-Amyloid Oligomers in Aqueous Solution Using Coarse-Grained Protein Models (Yassmine Chebaro and Philippe Derreumaux); Pathways of Amyloid Fibril Formation Using a Simplified Peptide Model (Riccardo Pellarin); From Disordered Amyloid β-Proteins to Soluble Oligomers and Protofibrils Using Discrete Molecular Dynamics (Mark Betnel, Nikolay V Dokholyan and Brigita Urbanc); Aβ Proteins - Lipid Membrane Interaction: Computational Simulation Study (Yuguang Mu); Molecular Insights into the Assembly of β-Amyloid on Surfaces and Carbon Nanotubes (Guanghong Wei, Yin Luo and Zhaoming Fu); Inhibiting Peptide and Protein Self-Aggregation: What Can Simulations Tell Us? (Joan-Emma Shea and Giorgio Colombo).