Morphological and Functional Aspects of Immunity

September 1.- Session 1 Ontogeny and Phylogeny of Immune Response.- New Observations on lymph Gland (LMl) and Thymus Activity in Larval Bullfrogs, Rana Catesbeiana.- The Use of Surface Alloantigenic Markers to Study the Differentiation of Thymus-Derived Lymphocytes in Mice.- A New Theoretical Model of Plasma Cell Differentiation.- The Rabbit Appendix: A Central or Peripheral Lymphoid Organ?.- Immunoglobulin Gene Expression in Immunocyte Differentiation.- Chairman's introduction to discussion.- The Maturation of Lymphoid Tissue Structure and Function in Ontogeny.- Discussion.- Session 2 Origin and Interaction of Immunologically Active Cells.- Studies on the Transfer of Natural E. Coli Antibody Production in Rats.- Lymphoid Cells Reacting Against 'Self' and their Possible Role in Immune Responses.- In Vitro Interaction Between Bone Marrow-Derived and Thymus Cells.- Cell Interactions in the In Vitro Production of Antibodies to Chemically Defined Antigens.- Chairman's introduction to discussion.- Origin and Interaction of Immunologically Active Cells.- Discussion.- Invited Speaker of the Day:.- Interaction between T Cells and B Cells in Humoral Antibody Responses.- Session 3 Lymphoid Cell Migration.- Quantitative Studies of Thymocytokinetics.- Migration of Thymic Lymphocytes: Immunofluorescence and 3HTdR Labeling Studies.- Homing of Cells from the Bursa of Fabricius to Germinal Centers in the Chicken Spleen.- Immune Competence of Cells Derived from Hemopoietic Liver after Traffic to Thymus.- The Fate of Lymph-Borne Immunoblasts.- Massive Migration of Thymic Lymphocytes to Peyer's Patches in Neonatal Mice.- Chairman's introduction to discussion.- Lymphoid Cell Migration.- Discussion.- September 2.- Session 4 Lymphatic Tissue and Germinal Centers in Relation to Antibody Production.- Histological Changes of Lymphoid Tissues in Relation to the Ontogeny of the Immune Response in Germfree Piglets.- Sites of Specific Antibody Production after Injection of Human Serum Albumin (HSA) in Complete Freund-type Adjuvant in the Chicken.- Fate and Immunogenicity of Antigens Endocytosed by Macrophages.- Cellular and Immunological Events following Injection of Antigen into the Chicken Thymus.- Chairman's introduction to discussion.- Lymphatic Tissue and Germinal Centers in Relation to Antibody Production.- Discussion.- Session 5 Localization of Antigen and Immune Complexes in Lymphatic Tissue with Special Reference to Germinal Centers.- The Mechanism of Antigen Localization in Lymphoid Follicles and the Patterns of Localization of Tolerance-inducing Flagellar Proteins.- Accelerated and Enhanced Germinal Center Development in Regional Lymph Nodes of Mice Following Primary Stimulation with Antigen-Antibody Complexes as compared to Antigen Only.- Lymph Node Response to Antigen-Antibody Complexes and the Fate of Injected Primed Lymphocytes in a Tolerant Host.- Mechanism of Interaction between Immune Complexes and Receptors for Antibody on Macrophages.- Follicular Localization of Antigen: Possible Role of Lymphocytes Bearing a Receptor for Antigen-Antibody-Complement Complexes.- Chairman's introduction to discussion.- Localization of Antigen and Immune Complexes in Lymphatic Tissue, with Special Reference to Germinal Centers.- Discussion.- Invited Speaker of the Day:.- Role of Inductive Microenvironments on Hemopoietic (and Lymphoid?) Differentiation, and Role of Thymic Cells in the Eosinophilic Granulocyte Response to Antigen.- Session 6 Immunologically Active Cell Kinetics (Models).- An In Vitro Model System for the Study of the Induction of Cellular Immunity.- Primary Immune Reaction of Allogeneic Lymph Node Cells Against Tissue Antigens of Lethally Irradiated Hosts.- An Alternative Model of Antibody Forming Cell Differentiation.- A Quantitative Model for the Mechanism of Antibody Formation and Tolerance.- Chairman's introduction to discussion.- Modelling of the Immune Processes.- Discussion.- September 3.- Session 7 Regulation of Lymphatic Tissue Function.- Attempt to Separate Antibody-Forming Clones of Different Affinity for One Antigenic Determinant on a Macromolecule.- Cellular Immunity in Vitro; Specific Antigen Induces Sensitization and Activates a Nonspecific Cytolytic Effect.- Control of Lymphocyte Growth in Response to Phytohemagglutinin Stimulation.- Studies of the Mechanism of Prevention of Immunologic Deficiency in Suckling Dwarf Mice.- Chairman's introduction to discussion.- The Regulation of Antibody Formation.- Discussion.- Session 8 Modification of Immune Response by External Agents with Special Reference to Germinal Centers.- A Quantitative Assessment of Cellular Recovery in Lymphoid Tissue.- A Study of the Properties and Effects of Anti-Macrophage Sera.- Effect of L-Asparaginase on Thymus-Dependent Immune Reactivity.- The Ultrastructure of Antibody-Forming Spleen Cells in Immunologically Suppressed Leukemic Mice.- Effects of Antilymphocyte Serum on the Localization of 1251-Labeled Flagella, Colloidal Carbon, and Titanium Dioxide in Splenic Lymphoid Follicles.- Electron Microscopic Observations in Rat Lymph Nodes Following Injection of AMS and ATS.- Chairman's introduction to discussion.- Modification of the Immune Response by External Agents. An Introduction to the Discussion.- Discussion.- Invited Speaker of the Day:.- Surface Antigens of Immunocompetent Cells.- Session 9 Tolerance and Autosensitization.- The Side Effects of High Zone Tolerance.- The Mechanism of Breakdown of Immune Tolerance to Protein Antigen in Rabbits.- Presence of Antigen Binding Cells in Mice Tolerant to E. Coli Polysaccharide.- Cellular and Humoral Aspects of "High and Low Dose" Tolerance to Sheep Erythrocytes in Mice.- Comparative Studies of Antigen Injected into Adults and Neonatal Rabbits.- Chairman's introduction to discussion.- Induction and Termination of Immunological Unresponsiveness.- Discussion.- September 4.- Session 10 Neoplastic Disease and the Immune System.- Immunological Reactivity of Mice Injected with Leukemic Cells.- In Vitro Immunization for Immunotherapy.- Cellular Immunity, Its Serum Mediated Inhibition and Tumor-Distinctive Anergy to Tumors in Man.- Tumor Induction by Murine Leukemia/Sarcoma Viruses: Morphological and Immunological Studies.- Chairman's introduction to discussion.- Factors Contributing to the "Success" of Antigenic Tumours.- Discussion.- Session 11 Free Session.- Lymphofollicular Hyperplastic Responses in Ectopic Locations: Trachoma as a Paradigm.- The Bone Marrow Origin of Lymphoid Primary Follicle Small Lymphocytes.- Effect of Partial Hepatectomy on Immune Responses. II. Enhancing Effect on Antigen Primed lymphocytes.- Regulation of the Immune Response. IV. The Role of the Fc-Fragment in Feedback Inhibition by Antibody.- The Role of the Bursa of Fabricius in the Recovery from Immunologic Tolerance to Bovine Serum Albumin.- Cell Destructive Action of Phytohaemagglutinin (PHA)-Stimulated Human Lymphocytes; Studies on the Mechanism of this Cyto-aggressive effect in Vitro.- On the Mechanism of Germinal Center Formation.- Appendix and Bone Marrow Cell Synergism in Early Antibody Response to Sheep Erythrocytes.- Thymus-Marrow Cell Interaction In Vitro. Enhancing Effect of Different Bone Marrow Constituents on PHA Response of Thymocytes.- Migration, Recirculation and Transformation of Large Dividing Lymph Node Cells in Syngeneic Recipient Rats Following Intravenous Injection.- Immunosuppression by L-Asparginase.- Immunosuppressive Properties and Side Effects of E. Coli L-Asparaginase.- Chronic Histoincompatibility and Lymphomagenesis in Mice.- Immunological Effects of Cortisone Caused by Interference with Lymphoid Cell Traffic.- Immunological Unresponsiveness to Soluble Antigens in Adult Mice.- The Immobilization of Lymphoid Cells in the Developing Palatine Tonsil of the Rabbit.