Essential Concepts in Molecular Pathology

William B. Coleman, PhD is the Executive Officer for the American Society for Investigative Pathology (Rockville, MD). Prior to taking this position with the American Society for Investigative Pathology, Dr. Coleman spent 28 years at the University of North Carolina School of Medicine (Chapel Hill, NC), first as a postdoctoral fellow (1990-1995) and then as a faculty member (1995-2018) in the Department of Pathology and Laboratory Medicine. During his time at the UNC School of Medicine, Dr. Coleman served as Director of Graduate Studies for the Molecular and Cellular Pathology Ph.D. Program (2006-2012; now the Pathobiology and Translational Medicine Ph.D. Program), was a co-founder of the UNC Program in Translational Medicine and served as its Co-Director (2006-2015) and then its Director (2015-2018), was affiliated with the Curriculum in Toxicology, the Cancer Biology Training Program, and was a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman was active in teaching biomedical graduate students and is a four-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at the UNC School of Medicine. Prior to becoming an employee, Dr. Coleman was active in the leadership of the American Society for Investigative Pathology, serving in various roles including President (2015-2016). Dr. Coleman was honored with the ASIP Outstanding Investigator Award in 2013 from the American Society for Investigative Pathology. He is also a long-time member of the American Association for Cancer Research. He serves as Senior Associate Editor for The American Journal of Pathology, and is an Associate Editor for BMC Cancer, and PLoS One, and serves on the editorial boards of Clinica Chimica Acta, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, Laboratory Investigation, and Current Pathobiology Reports, and has served as an ad hoc reviewer for 99 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research was funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 140 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored ten books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer. Gregory J. Tsongalis, PhD, HCLD, CC, FNACB., is the Vice Chair for Research and the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) in the Department of Pathology and Laboratory Medicine at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH. He is a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH and a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program and Diagnostic Genetic Sciences Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 230 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the American Association for Clinical Chemistry, the American Society for Investigative Pathology, the Federation for American Societies for Experimental Biology, and the Association for Molecular Pathology (where he is a past President). He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalysts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. In 2016, Dr. Tsongalis received the Norris Cotton Cancer Center Award for Excellence, in 2017 the Association for Molecular Pathology (AMP) Jeffrey A. Kant Leadership Award, and in 2019 the American Society for Investigative Pathology Robbins Distinguished Educator Award. He also serves on numerous corporate scientific advisory boards.

PART I Essential Pathology - Mechanisms of Disease
1 Cell Injury, Cell Death, and Cellular Adaptation
John J. Lemasters, M.D., Ph.D.
2 Acute and Chronic Inflammation
Vladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D.
3 Infection and Host Response
Sheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D.
4 Neoplasia
William B. Coleman, Ph.D., and Tara Rubinas, M.D.

PART II Concepts in Molecular Biology and Genetics
5 Basic Concepts in Human Molecular Genetics
W. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C.
6 The Human Genome: Implications for the Understanding of Human Disease
William B. Coleman, Ph.D, Gregory J. Tsongalis, Ph.D. and Ashley Rivenbark, M.D.
7 The Human Transcriptome: Implications for the Understanding of Human Disease
Reinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D.
8 The Human Epigenome: Implications for the Understanding of Human Disease
Manel Esteller, Ph.D. and Maria Berdasco, Ph.D.
9 The Human Proteome: Implications for the Understanding of Human Disease
Lance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin
10 Integrative Systems Biology: Implications for the Understanding of Human Disease
M. Michael Barmada, Ph.D. and David C. Whitcomb

PART III Principles and Practice of Molecular Pathology
11 Pathology: The Clinical Description of Human Disease
William K. Funkhouser, M.D., Ph.D.
12 Molecular Pathogenesis: The Biological Basis of Human Disease
William B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D.
13 Integration of Molecular and Cellular Pathogenesis
Jason H. Moore, Ph.D., and C. Harker Rhodes, M.D.

PART IV Molecular Pathology of Human Disease
14 Molecular Basis of Cardiovascular Disease
Avrum I. Gotlieb, M.D.C.M. and Amber Chang Liu
15 Molecular Basis of Hemostatic and Thrombotic Diseases
Nigel S. Key, M.D., and Alice Ma, M.D.
16 Molecular Basis of Lymphoid and Myeloid Diseases
Dong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D.
17 Molecular Basis of Diseases of Immunity
David O. Beenhouwer, Ph.D.
18 Molecular Basis of Pulmonary Disease
Dani S. Zander, M.D., and Carol Farver, M.D.
19 Molecular Basis of Diseases of the Gastrointestinal Tract
Antonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D.
20 Molecular Basis of Liver Disease
Satdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D.
21 Molecular Basis of Diseases of the Exocrine Pancreas
Markus M. Lerch, M.D.
22 Molecular Basis of Diseases of the Endocrine System
Malcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D.
23 Molecular Basis of Gynecologic Diseases
Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D.
24 Molecular Pathogenesis of Diseases of the Kidney
Amy K. Mottl, M.D., M.P.H., and Carla Nester, M.D., M.S.A.
25 Molecular Basis of Prostate Disease
William G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D.
26 Molecular Basis of Breast Disease
Christos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe Bedard
Translational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium
27 Molecular Basis of Skin Disease
John A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D.
28 Molecular Basis of Diseases of the Nervous System
Joshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D.
 
PART V Practice of Molecular Medicine
29 Molecular Diagnosis of Human Disease
Grant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D.
30 Molecular Assessment of Human Disease in the Clinical Laboratory
Gregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D.
31 Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease
Gregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D.