Advances in Immunology

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Learning from leprosy: insight into the human innate immune response

Dennis Montoya and Robert L. Modlin

2. The immunological functions of saposins

Alexandre Darmoise, Patrick Maschmeyer and Florian Winau



OX40-OX40 ligand interaction in T cell-mediated immunity and immunopathology

Naoto Ishii, Takeshi Takahashi, Pejman Soroosh, and Kazuo Sugamura

4.The family of IL-10-secreting CD4+ T cells

Keishi Fujio, Tomohisa Okamura, and Kazuhiko Yamamoto

5.Artificial engineering of secondary lymphoid organs

Jonathan K.H. Tan and Takeshi Watanabe

6. Aid And Somatic Hypermutation

Robert W. Maul and Patricia J. Gearhart

7. BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis

Katia Basso and Riccardo Dalla-Favera