Epigenetics and DNA Damage

Dr. Miriam Galvonas Jasiulionis is a Professor at the Department of Pharmacology, in the Laboratory of Ontogeny and Epigenetics, at the Universidade Federal de São Paulo, Brazil. Her lab has investigated the role of epigenetic alterations in the relationship between sustained stressful conditions and malignant transformation, especially in melanocytes, to contribute to better comprehension of mechanisms involved in melanoma genesis and open avenues to develop novel therapeutic approaches. Dr. Jasiulionis has published widely in such peer reviewed journals as Clinical Epigenetics, Molecular Oncology, Frontiers in Immunology, Oncotarget, Epigenetics, and Neoplasia.

1. Introduction Miriam Galvonas Jasiulionis
2. DNA damage and DNA methylation
3. DNA damage and histone modifications
4. DNA damage and histone variants
5. DNA damage and chromatin regulators
6. DNA damage and miRNAs
7. DNA damage and lncRNAs
8. DNA damage, SIRT1 and epigenetic marks
9. DNA damage, metabolic alterations and epigenetic changes
10. DNA damage, diet and epigenetic changes
11. DNA damage, epigenetics and aging
12. DNA damage, epigenetics and pluripotent stem cell differentiation
13. DNA damage, epigenetics and chronic inflammatory diseases
14. DNA damage, epigenetic alterations and immune dysfunction
15. DNA repair, epigenetics and trinucleotide repeat ataxias
16. DNA damage, epigenetics and cancer
17. Oncometabolites, epigenetic marks and DNA repair
18. Therapies inducing DNA damage
19. Epigenetic therapy
20. Therapeutic strategies combining damage induction and epigenetic alterations
21. Useful protocols to study DNA damage
22. Useful protocols to study epigenetic modifications
23. Interplay between DNA repair and epigenetics: Future directions