Epigenetics in Human Disease

Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.

Section I: Introduction 1. Epigenetics in Human Disease

Section II: Methodology 2. Methods and Strategies to Determine Epigenetic Variation in Human Disease 3. Age Estimates Using DNA Methylation Patterns 4.Bioinformatics of Epigenetic Data Generated from Next-generation Sequencing

Section III: Human Cancer 5. DNA Methylation Alterations in Human Cancers 6. Alterations of Histone Modifications in Cancer 7. MicroRNA in Cancer 8. Epigenetic Approaches to Cancer Therapy

Section lV: Neurological Disease 9. Epigenomics in Neurobehavioral Disease 10. Emerging Role of Epigenetics in Human Neurodevelopmental Disorders 11. The Epigenetics of Alzheimer’s and Other Neurodegenerative Disease 12. Epigenetic Modulation of Human Neurobiological Disorder

Section V: Autoimmune Disease 13. Epigenetic Basis of Autoimmune Disorders in Humans 14. Approaches to Autoimmune Diseases Using Epigenetic Therapy

Section VI: Metabolic Disorders 15. Epigenomic Factors in Human Obesity 16. Epigenetic Approaches to Control Obesity 17. Epigenetics of Diabetes in Humans 18. The Potential of Epigenetic Compounds in Treating Diabetes

Section VII: Other Disorders/Diseases 19. Epigenetic Aberrations in Human Allergic Diseases 20. Therapy of Airway Disease: Epigenetic Potential 21. The Role of Epigenetics in Cardiovascular Disease 22. Epigenetic Treatment Approaches to Cardiovascular Disease 23. Epigenetics and Human Infectious Diseases 24. Therapy of Infectious Diseases Using Epigenetic Approaches 25. The Epigenetics of Endometriosis 26. Epigenetic DNA Methylation in Endometrial Cancer 27. Epigenetic Treatment Prospects of Gynecological and Reproductive Diseases

Section VIII: Development, Aging and Transgenerational Effects 28. Epigenetics of Transgenerational Inheritance in Disease 29. Epigenetic Mechanisms of Human Imprinting Disorders 30. Therapeutic Approaches to Imprinting Diseases 31. Stem Cell Epigenetics and Human Disease 32. Non-coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy 33. Aging and Disease: The Epigenetic Bridge 34. Epigenetic Programming of Human Disease and Aging

Section lV: Future Research 35. Future Directions in the Epigenetics of Human Disease