Nuclear Architecture and Dynamics

Christophe Lavelle, Volume Editor, is a research scientist at the CNRS (National Center for Scientific Research), principal investigator at the National Museum of Natural History in Paris. His studies mostly concern the biophysical properties of DNA and dynamical processes at task in the nucleus. He teaches biophysics and epigenetics in several universities (Paris VI, Paris VII, Aix-Marseille, Lyon, Lille, Toulouse) and is a member of the American and the French Biophysical Societies. Jean-Marc Victor, Volume Editor, is a research director at the CNRS, principal investigator at the University Pierre et Marie Curie - Paris VI (part of Sorbonne University). His studies mostly concern the physics of chromosomes (theory and simulations) and the modeling of nuclear processes, with special attention to epigenetics and chronic diseases.

PART I - CHROMATIN ORGANIZATION AND DYNAMICS 1. DNA mechanics 2. DNA supercoiling (omics) 3. Chromatin and chromosome folding (experiments) 4. Chromatin and chromosome folding (modeling) 5. Chromatin and chromosome physics 6. ncRNA in chromatin folding 7. Insulators 8. Condensins and cohesins 9. Long range interactions 10. Crowding

PART II - NUCLEAR ENVELOPE, NUCLEAR BODIES AND NUCLEOCYTOPLASMIC TRAFFICKING 11. Nuclear bodies 12. Nucleolus 13. Transcription factories 14. Polycomb bodies 15. Nuclear lamina 16. Other components of the nucleoskeleton 17. Nuclear pores 18. Nuclear traffic

PART III - MAIN NUCLEAR FUNCTIONS 19. Chromatin folding and DNA replication 20. Chromatin folding and DNA repair 21. Chromatin folding and transcription 22. Chromatin folding and recombination 23. Chromatin folding and differentiation 24. Nuclear mechanics and mechanotransduction 25. Altered nucleus and disease

PART IV - SPECIFIC FEATURES OF NUCLEAR ORGANIZATION IN MAIN MODEL ORGANISMS 26. Yeast nucleus 27. Nematode nucleus 28. Drosophila nucleus 29. Plant nucleus Conclusion and perspectives by the editors